SEPARATION OF BASIC DRUGS BY CAPILLARY ELECTROPHORESIS USING SELECTIVELY MODIFIED CYCLODEXTRINS AS CHIRAL SELECTORS

被引：41
|
作者：
WESELOH, G [1 ]
BARTSCH, H [1 ]
KONIG, WA [1 ]
机构：
[1] UNIV HAMBURG,INST ORGAN CHEM,D-20146 HAMBURG,GERMANY
来源：
JOURNAL OF MICROCOLUMN SEPARATIONS | 1995年 / 7卷 / 04期
关键词：
BASIC DRUGS; CAPILLARY ELECTROPHORESIS; CYCLODEXTRIN DERIVATIVES; SEPARATION OF ENANTIOMERS;
D O I：
10.1002/mcs.1220070408
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The influence of seven differently methylated beta-cyclodextrin derivatives and of pure beta-cyclodextrin (beta-CD) on the enantiomeric resolution by capillary electrophoresis of six basic chiral pharmaceuticals is investigated. The methyl substitution pattern affects enantioselectivity much more than other experimental parameters. The purity of the used cyclodextrin derivatives is analyzed by successive hydrolysis, reduction, acetylation, and GC/MS of each CD derivative and by MALDI-TOF mass spectrometry. (C) 1995 John Wiley & Sons, Inc.
引用
收藏
页码：355 / 363
页数：9
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