FEEDFORWARD CONTROL OF AGONIST-INDUCED CA2+ SIGNALING BY PROTEIN-KINASE-C IN AIRWAY SMOOTH-MUSCLE CELLS

被引：9

作者：

HOITING, BH

KUIPERS, R

ELZINGA, CRS

ZAAGSMA, J

MEURS, H

机构：

[1] Department of Medicinal Chemistry and Molecular Pharmacology, University Center for Pharmacy, 9713 AW Groningen

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1995年 / 290卷 / 02期

关键词：

PROTEIN KINASE C; CA2+; AIRWAY SMOOTH MUSCLE;

D O I：

10.1016/0922-4106(95)90033-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In isolated bovine tracheal smooth muscle cells, the potent and specific protein kinase C inhibitor GF 109203X caused an inhibition of methacholine-and histamine-induced Ca2+ mobilization and influx, indicating for the first time that protein kinase C activation induced by contractile agonists exerts a positive feedforward control of Ca2+ signalling by these agonists.

引用

页码：R5 / R7

页数：3

共 8 条

[1] HISTAMINE-INDUCED CALCIUM RELEASE AND PHORBOL ANTAGONISM IN CULTURED AIRWAY SMOOTH-MUSCLE CELLS [J].

KOTLIKOFF, MI ;

MURRAY, RK ;

REYNOLDS, EE .

AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (04) :C561-C566

[2] EVIDENCE FOR A DIRECT RELATIONSHIP BETWEEN PHOSPHOINOSITIDE METABOLISM AND AIRWAY SMOOTH-MUSCLE CONTRACTION INDUCED BY MUSCARINIC AGONISTS [J].

MEURS, H ;

ROFFEL, AF ;

POSTEMA, JB ;

TIMMERMANS, A ;

ELZINGA, CRS ;

KAUFFMAN, HF ;

ZAAGSMA, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 156 (02) :271-274

[3] RECEPTOR-ACTIVATED CALCIUM INFLUX IN HUMAN AIRWAY SMOOTH-MUSCLE CELLS [J].

MURRAY, RK ;

KOTLIKOFF, MI .

JOURNAL OF PHYSIOLOGY-LONDON, 1991, 435 :123-144

[4] INTRACELLULAR SIGNALING BY HYDROLYSIS OF PHOSPHOLIPIDS AND ACTIVATION OF PROTEIN-KINASE-C [J].

NISHIZUKA, Y .

SCIENCE, 1992, 258 (5082) :607-614

[5] CAPACITATIVE CALCIUM ENTRY REVISITED [J].

PUTNEY, JW .

CELL CALCIUM, 1990, 11 (10) :611-624

[6] PROTEIN-KINASE-C IN THE REGULATION OF SMOOTH-MUSCLE CONTRACTION [J].

RASMUSSEN, H ;

TAKUWA, Y ;

PARK, S .

FASEB JOURNAL, 1987, 1 (03) :177-185

[7]

TOULLEC D, 1991, J BIOL CHEM, V266, P15771

[8] ROLE OF PHOSPHOINOSITIDE METABOLISM IN HUMAN BRONCHIAL SMOOTH-MUSCLE CONTRACTION AND IN FUNCTIONAL ANTAGONISM BY BETA-ADRENOCEPTOR AGONISTS [J].

VANAMSTERDAM, RGM ;

MEURS, H ;

TENBERGE, REJ ;

VENINGA, NCM ;

BROUWER, F ;

ZAAGSMA, J .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (05) :1124-1128

← 1 →