ASSIGNMENT OF THE HUMAN GENE FOR THE ALPHA-1 SUBUNIT OF THE SKELETAL-MUSCLE DHP-SENSITIVE CA2+ CHANNEL (CACNL1A3) TO CHROMOSOME-1Q31-Q32

被引：55
作者：
GREGG, RG
COUCH, F
HOGAN, K
POWERS, PA
机构：
[1] UNIV WISCONSIN,DEPT ANESTHESIOL,MADISON,WI 53705
[2] UNIV WISCONSIN,DEPT PEDIAT,MADISON,WI 53705
来源：
GENOMICS | 1993年 / 15卷 / 01期
关键词：
D O I：
10.1006/geno.1993.1017
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A human clone corresponding to the gene encoding the α1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (CACNL1A3) has been isolated and partially sequenced. Oligonucleotides based on this sequence were used in a polymerase chain reaction to amplify specifically the human gene in human-rodent somatic cell hybrids, allowing the assignment of CACNL1A3 to chromosome 1. A polymorphic dinucleotide repeat also was identified in the human clone and using PCR was typed on a subset of the CEPH families. Multipoint linkage analysis places the CACNL1A3 gene between D1S52 and D1S70, on chromosome 1q31-q32. © 1993 Academic Press. All rights reserved.
引用
收藏
页码：107 / 112
页数：6
相关论文
共 40 条
  • [21] McKusick VA, 1990, MENDELIAN INHERITANC
  • [22] PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF THE CARDIAC DIHYDROPYRIDINE-SENSITIVE CALCIUM-CHANNEL
    MIKAMI, A
    IMOTO, K
    TANABE, T
    NIIDOME, T
    MORI, Y
    TAKESHIMA, H
    NARUMIYA, S
    NUMA, S
    [J]. NATURE, 1989, 340 (6230) : 230 - 233
  • [23] PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION FROM COMPLEMENTARY-DNA OF A BRAIN CALCIUM-CHANNEL
    MORI, Y
    FRIEDRICH, T
    KIM, MS
    MIKAMI, A
    NAKAI, J
    RUTH, P
    BOSSE, E
    HOFMANN, F
    FLOCKERZI, V
    FURUICHI, T
    MIKOSHIBA, K
    IMOTO, K
    TANABE, T
    NUMA, S
    [J]. NATURE, 1991, 350 (6317) : 398 - 402
  • [24] DEVELOPMENTAL GENETICS OF A LETHAL MUTATION MUSCULAR DYSGENESIS ( MDG ) IN MOUSE .1. GENETIC ANALYSIS AND GROSS MORPHOLOGY
    PAI, AC
    [J]. DEVELOPMENTAL BIOLOGY, 1965, 11 (01) : 82 - &
  • [25] DEVELOPMENTAL GENETICS OF A LETHAL MUTATION MUSCULAR DYSGENESIS ( MDG ) IN MOUSE .2. DEVELOPMENTAL ANALYSIS
    PAI, AC
    [J]. DEVELOPMENTAL BIOLOGY, 1965, 11 (01) : 93 - &
  • [26] INDUCTION OF CALCIUM CURRENTS BY THE EXPRESSION OF THE ALPHA-1-SUBUNIT OF THE DIHYDROPYRIDINE RECEPTOR FROM SKELETAL-MUSCLE
    PEREZREYES, E
    KIM, HS
    LACERDA, AE
    HORNE, W
    WEI, XY
    RAMPE, D
    CAMPBELL, KP
    BROWN, AM
    BIRNBAUMER, L
    [J]. NATURE, 1989, 340 (6230) : 233 - 236
  • [27] PEREZREYES E, 1990, J BIOL CHEM, V265, P20430
  • [28] ASSIGNMENT OF THE HUMAN GENE FOR THE ALPHA-1 SUBUNIT OF THE CARDIAC DHP-SENSITIVE CA2+ CHANNEL (CCHL1A1) TO CHROMOSOME-12P12-PTER
    POWERS, PA
    GREGG, RG
    LALLEY, PA
    LIAO, M
    HOGAN, K
    [J]. GENOMICS, 1991, 10 (03) : 835 - 839
  • [29] CALCIUM CHANNELS IN PLANAR LIPID BILAYERS - INSIGHTS INTO MECHANISMS OF ION PERMEATION AND GATING
    ROSENBERG, RL
    HESS, P
    REEVES, JP
    SMILOWITZ, H
    TSIEN, RW
    [J]. SCIENCE, 1986, 231 (4745) : 1564 - 1566
  • [30] PRIMARY STRUCTURE OF THE BETA-SUBUNIT OF THE DHP-SENSITIVE CALCIUM-CHANNEL FROM SKELETAL-MUSCLE
    RUTH, P
    ROHRKASTEN, A
    BIEL, M
    BOSSE, E
    REGULLA, S
    MEYER, HE
    FLOCKERZI, V
    HOFMANN, F
    [J]. SCIENCE, 1989, 245 (4922) : 1115 - 1118
1234