ASSIGNMENT OF THE HUMAN GENE FOR THE ALPHA-1 SUBUNIT OF THE SKELETAL-MUSCLE DHP-SENSITIVE CA2+ CHANNEL (CACNL1A3) TO CHROMOSOME-1Q31-Q32

被引：55

作者：

GREGG, RG

COUCH, F

HOGAN, K

POWERS, PA

机构：

[1] UNIV WISCONSIN,DEPT ANESTHESIOL,MADISON,WI 53705

[2] UNIV WISCONSIN,DEPT PEDIAT,MADISON,WI 53705

来源：

GENOMICS | 1993年 / 15卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1017

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A human clone corresponding to the gene encoding the α1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (CACNL1A3) has been isolated and partially sequenced. Oligonucleotides based on this sequence were used in a polymerase chain reaction to amplify specifically the human gene in human-rodent somatic cell hybrids, allowing the assignment of CACNL1A3 to chromosome 1. A polymorphic dinucleotide repeat also was identified in the human clone and using PCR was typed on a subset of the CEPH families. Multipoint linkage analysis places the CACNL1A3 gene between D1S52 and D1S70, on chromosome 1q31-q32. © 1993 Academic Press. All rights reserved.

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页码：107 / 112

页数：6

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