EVOLUTION OF THE MAMMALIAN G-PROTEIN ALPHA-SUBUNIT MULTIGENE FAMILY

被引：237
作者：
WILKIE, TM
GILBERT, DJ
OLSEN, AS
CHEN, XN
AMATRUDA, TT
KORENBERG, JR
TRASK, BJ
DEJONG, P
REED, RR
SIMON, MI
JENKINS, NA
COPELAND, NG
机构：
[1] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21702
[2] CALTECH,DIV BIOL 14775,PASADENA,CA 91125
[3] JOHNS HOPKINS UNIV,SCH MED,HOWARD HUGHES MED INST,DEPT MOLEC BIOL & GENET,BALTIMORE,MD 21205
[4] LAWRENCE LIVERMORE NATL LAB,DIV BIOMED SCI L452,LIVERMORE,CA 94550
[5] CEDARS SINAI MED CTR,DEPT PEDIAT,CTR BIRTH DEFECTS,LOS ANGELES,CA 90048
来源：
NATURE GENETICS | 1992年 / 1卷 / 02期
关键词：
D O I：
10.1038/ng0592-85
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Heterotrimeric guanine nucleotide binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. The multigene family of G protein alpha-subunits, which interact with receptors and effectors, exhibit a high level of sequence diversity. In mammals, 15 G-alpha subunit genes can be grouped by sequence and functional similarities into four classes. We have determined the murine chromosomal locations of all 15 G-alpha subunit genes using an interspecific backcross derived from crosses of C57BL/6J and Mus spretus mice. These data, in combination with mapping studies in humans, have provided insight into the events responsible for generating the genetic diversity found in the mammalian alpha-subunit genes and a framework for elucidating the role of the G-alpha subunits in disease.
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页码：85 / 91
页数：7
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