STRUCTURAL REQUIREMENTS OF OLEFINIC 5-SUBSTITUTED DEOXYURIDINES FOR ANTIHERPES ACTIVITY

被引:77
作者
GOODCHILD, J [1 ]
PORTER, RA [1 ]
RAPER, RH [1 ]
SIM, IS [1 ]
UPTON, RM [1 ]
VINEY, J [1 ]
WADSWORTH, HJ [1 ]
机构
[1] GD SEARLE & CO LTD,SEARLE RES & DEV,DEPT BIOL,HIGH WYCOMBE HP12 4HL,BUCKS,ENGLAND
关键词
D O I
10.1021/jm00363a009
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1252 / 1257
页数:6
相关论文
共 29 条
[1]   ON THE MECHANISM OF SELECTIVE-INHIBITION OF HERPESVIRUS REPLICATION BY (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE [J].
ALLAUDEEN, HS ;
KOZARICH, JW ;
BERTINO, JR ;
DECLERCQ, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (05) :2698-2702
[2]  
Barwolff D., 1978, NUCL ACID CHEM, V1, P359
[3]  
BENNETT MA, 1965, CHEM IND-LONDON, P846
[4]   C-5-SUBSTITUTED PYRIMIDINE NUCLEOSIDES .3. REACTION OF ALLYLIC CHLORIDES, ALCOHOLS, AND ACETATES WITH PYRIMIDINE NUCLEOSIDE DERIVED ORGANOPALLADIUM INTERMEDIATES [J].
BERGSTROM, DE ;
RUTH, JL ;
WARWICK, P .
JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (07) :1432-1441
[5]  
BERGSTROM DE, 1977, J CARB-NUCLEOS-NUCL, V4, P257
[6]   ANTI-HERPES SIMPLEX VIRUS AND ANTI-HUMAN CELL-GROWTH ACTIVITY OF E-5-PROPENYL-2'-DEOXYURIDINE AND THE CONCEPT OF SELECTIVE PROTECTION IN ANTIVIRUS CHEMOTHERAPY [J].
CHENG, YC ;
GRILL, S ;
RUTH, J ;
BERGSTROM, DE .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 18 (06) :957-961
[7]  
CHENG YC, 1981, MOL PHARMACOL, V20, P230
[8]   ANTIVIRAL ACTION AND CELLULAR TOXICITY OF 4 THYMIDINE ANALOGS - 5-ETHYL-DEOXYURIDINE, 5-VINYL-DEOXYURIDINE, 5-PROPYL-DEOXYURIDINE, AND 5-ALLYL-2'-DEOXYURIDINE [J].
CHENG, YC ;
DOMIN, BA ;
SHARMA, RA ;
BOBEK, M .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (01) :119-122
[9]   INDUCTION OF THYMIDINE KINASE AND DNASE IN VARICELLA-ZOSTER VIRUS-INFECTED CELLS AND KINETIC-PROPERTIES OF THE VIRUS-INDUCED THYMIDINE KINASE [J].
CHENG, YC ;
TSOU, TY ;
HACKSTADT, T ;
MALLAVIA, LP .
JOURNAL OF VIROLOGY, 1979, 31 (01) :172-177
[10]  
DECLERCQ E, 1982, MOL PHARMACOL, V21, P217