STRUCTURAL REQUIREMENTS OF OLEFINIC 5-SUBSTITUTED DEOXYURIDINES FOR ANTIHERPES ACTIVITY

被引：77

作者：

GOODCHILD, J ^{[1
]}

PORTER, RA ^{[1
]}

RAPER, RH ^{[1
]}

SIM, IS ^{[1
]}

UPTON, RM ^{[1
]}

VINEY, J ^{[1
]}

WADSWORTH, HJ ^{[1
]}

机构：

[1] GD SEARLE & CO LTD,SEARLE RES & DEV,DEPT BIOL,HIGH WYCOMBE HP12 4HL,BUCKS,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1983年 / 26卷 / 09期

关键词：

D O I：

10.1021/jm00363a009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1252 / 1257

页数：6

共 29 条

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[3] BENNETT MA, 1965, CHEM IND-LONDON, P846
[4] C-5-SUBSTITUTED PYRIMIDINE NUCLEOSIDES .3. REACTION OF ALLYLIC CHLORIDES, ALCOHOLS, AND ACETATES WITH PYRIMIDINE NUCLEOSIDE DERIVED ORGANOPALLADIUM INTERMEDIATES
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[5] BERGSTROM DE, 1977, J CARB-NUCLEOS-NUCL, V4, P257
[6] ANTI-HERPES SIMPLEX VIRUS AND ANTI-HUMAN CELL-GROWTH ACTIVITY OF E-5-PROPENYL-2'-DEOXYURIDINE AND THE CONCEPT OF SELECTIVE PROTECTION IN ANTIVIRUS CHEMOTHERAPY
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[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 18 (06) : 957 - 961
[7] CHENG YC, 1981, MOL PHARMACOL, V20, P230
[8] ANTIVIRAL ACTION AND CELLULAR TOXICITY OF 4 THYMIDINE ANALOGS - 5-ETHYL-DEOXYURIDINE, 5-VINYL-DEOXYURIDINE, 5-PROPYL-DEOXYURIDINE, AND 5-ALLYL-2'-DEOXYURIDINE
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[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (01) : 119 - 122
[9] INDUCTION OF THYMIDINE KINASE AND DNASE IN VARICELLA-ZOSTER VIRUS-INFECTED CELLS AND KINETIC-PROPERTIES OF THE VIRUS-INDUCED THYMIDINE KINASE
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TSOU, TY
HACKSTADT, T
MALLAVIA, LP
[J]. JOURNAL OF VIROLOGY, 1979, 31 (01) : 172 - 177
[10] DECLERCQ E, 1982, MOL PHARMACOL, V21, P217

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