A case of Hodgkin's lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD

被引：5

作者：

Chakraborty, Rajshekhar ^{[1
]}

Mukkamalla, Shiva Kumar Reddy ^{[2
]}

Gutzmore, Garfield ^{[2
]}

Chan, Hon Cheung ^{[2
]}

机构：

[1] Essentia Hlth, Hosp Serv, Brainerd, MN USA

[2] Queens Hosp Ctr, Icahn Sch Med Mt Sinai, Dept Internal Med, Jamaica, NY 11432 USA

来源：

JOURNAL OF BLOOD MEDICINE | 2015年 / 6卷

关键词：

hepatomegaly; cytogenetics; remission;

D O I：

10.2147/JBM.S67664

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hodgkin's lymphoma (HL) originates from clonal B cells and is the most common malignancy in the second decade of life. Liver involvement is uncommon at presentation in patients with HL and there is a paucity of data for treatment of patients with severely impaired liver function. We present an unusual case of HL with severe hepatic impairment, splenomegaly and multiple chromosomal abnormalities that was treated initially with gemcitabine and steroids. Once liver function tests improved, six cycles of Adriamycin, bleomycin, vinblastine, and dacarbazine were administered. The patient remains in remission at 3.5 years of follow-up.

引用

页码：93 / 97

页数：5

共 25 条

[1] Gemcitabine, dexamethasone and cisplatin is an active and non-toxic chemotherapy regimen in relapsed or refractory Hodgkin's disease: a phase II study by the National Cancer Institute of Canada Clinical Trials Group [J].