SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1-(4-ARYL-2-THIAZOLYL) - AND 1-( 4-ARYL-2-OXAZOLYL)-3, 5-DIARYL Delta(2)-PYRAZOLINE DERIVATIVES

被引：0
|
作者：
Dawood, Nadia T. A. [1 ]
机构：
[1] Girls Al Azhar Univ, Fac Sci, Chem Dept, Cairo, Egypt
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2011年 / 2卷 / 09期
关键词：
Delta(2)-pynazolines; Thiazoles; Oxazoles; Synthesis; Antimicrobial activity;
D O I：
10.13040/IJPSR.0975-8232.2(9).2368-75
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A series of nine 1-(4-aryl-2-thiazolyl)-3, 5-diaryl and six of 1-(4-aryl-2oxazolyl)- 3, 5-diaryl-2-pyrazolin derivatives were prepared by reacting 3, 5diaryl- 1-thiocarbamoyl-/or 3, 5-diaryl-1-carbamoyl- Delta(2)-pyrazolines with substituted phenacyl bromide in ethanol. The structures of the synthesized derivatives were confirmed by IR, 1(H)-NMR, C-13-NMR as well as EIMS spectral data. Some of these derivatives were screened for their antimicrobial activity against Gram-positive, Gram-negative and pathogenic fungi, and showed a significant activity.
引用
收藏
页码：2368 / 2375
页数：8
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