5' CONTROL REGIONS OF THE APOLIPOPROTEIN(A) GENE AND MEMBERS OF THE RELATED PLASMINOGEN GENE FAMILY

被引：177

作者：

WADE, DP ^{[1
]}

CLARKE, JG ^{[1
]}

LINDAHL, GE ^{[1
]}

LIU, AC ^{[1
]}

ZYSOW, BR ^{[1
]}

MEER, K ^{[1
]}

SCHWARTZ, K ^{[1
]}

LAWN, RM ^{[1
]}

机构：

[1] ARRIS PHARMACEUT CORP, San Francisco, CA 94080 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 04期

关键词：

APOLIPOPROTEIN; ATHEROSCLEROSIS; LIPOPROTEIN(A);

D O I：

10.1073/pnas.90.4.1369

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Elevated blood levels of apolipoprotein(a), the component of lipoprotein(a) that distinguishes it from low density lipoprotein, are a major risk factor for atherosclerosis. The apolipoprotein(a) gene is highly similar to the plasminogen gene and to at least four other genes or pseudogenes. The 5' untranslated and flanking sequences of these six genes contain extensive regions of near identity and share sequence elements involved in the initiation of transcription and translation. About 1000 base pairs of flanking DNA of each gene are sufficient to promote transcription in cultured hepatocytes. The apolipoprotein(a) gene promoter contains functional interleukin 6-responsive elements, consistent with the reported acute-phase response of apolipoprotein(a). Flanking genomic fragments of the apoliprotein(a) gene from two individuals with vastly different plasma apolipoprotein(a) concentrations have sequence differences that are reflected in differences in the rate of in vitro transcription.

引用

页码：1369 / 1373

页数：5

共 37 条

[1] A NUCLEAR FACTOR FOR IL-6 EXPRESSION (NF-IL6) IS A MEMBER OF A C/EBP FAMILY [J].