THIOACYLATING INTERMEDIATES AS METABOLITES OF S-(1,2-DICHLOROVINYL)-L-CYSTEINE AND S-(1,2,2-TRICHLOROVINYL)-L-CYSTEINE FORMED BY CYSTEINE CONJUGATE BETA-LYASE

被引：94
作者：
DEKANT, W [1 ]
BERTHOLD, K [1 ]
VAMVAKAS, S [1 ]
HENSCHLER, D [1 ]
ANDERS, MW [1 ]
机构：
[1] UNIV ROCHESTER,DEPT PHARMACOL,ROCHESTER,NY 14642
来源：
CHEMICAL RESEARCH IN TOXICOLOGY | 1988年 / 1卷 / 03期
关键词：
D O I：
10.1021/tx00003a008
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：175 / 178
页数：4
相关论文
共 20 条
[1]   BIOSYNTHESIS AND BIOTRANSFORMATION OF GLUTATHIONE S-CONJUGATES TO TOXIC METABOLITES [J].
ANDERS, MW ;
LASH, L ;
DEKANT, W ;
ELFARRA, AA ;
DOHN, DR .
CRC CRITICAL REVIEWS IN TOXICOLOGY, 1988, 18 (04) :311-341
[2]  
BAUER W, 1984, METHODEN ORG CHEM, V14, P1243
[3]  
DEKANT W, 1987, DRUG METAB DISPOS, V15, P702
[4]   BACTERIAL BETA-LYASE MEDIATED CLEAVAGE AND MUTAGENICITY OF CYSTEINE CONJUGATES DERIVED FROM THE NEPHROCARCINOGENIC ALKENES TRICHLOROETHYLENE, TETRACHLOROETHYLENE AND HEXACHLOROBUTADIENE [J].
DEKANT, W ;
VAMVAKAS, S ;
BERTHOLD, K ;
SCHMIDT, S ;
WILD, D ;
HENSCHLER, D .
CHEMICO-BIOLOGICAL INTERACTIONS, 1986, 60 (01) :31-45
[5]  
DEKANT W, 1987, P NATL ACAD SCI US, V84, P1443
[6]   ASSAY OF CYSTEINE CONJUGATE BETA-LYASE ACTIVITY WITH S-(2-BENZOTHIAZOLYL)CYSTEINE AS THE SUBSTRATE [J].
DOHN, DR ;
ANDERS, MW .
ANALYTICAL BIOCHEMISTRY, 1982, 120 (02) :379-386
[7]   MECHANISM OF S-(1,2-DICHLOROVINYL)GLUTATHIONE-INDUCED NEPHROTOXICITY [J].
ELFARRA, AA ;
JAKOBSON, I ;
ANDERS, MW .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (02) :283-288
[8]  
ELFARRA AA, 1984, BIOCH PHARM, V33, P2729
[9]   STRUCTURE ACTIVITY STUDIES OF THE NEPHROTOXIC AND MUTAGENIC ACTION OF CYSTEINE CONJUGATES OF CHLOROALKENES AND FLUOROALKENES [J].
GREEN, T ;
ODUM, J .
CHEMICO-BIOLOGICAL INTERACTIONS, 1985, 54 (01) :15-31
[10]   NON-ENZYMATIC TRANSAMINATION AND BETA-ELIMINATION OF DL-S-BENZYLCYSTEINE CATALYZED BY A POTENT PYRIDOXAL MODEL [J].
KIKUCHI, J ;
SUNAMOTO, J ;
KONDO, H .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1985, (03) :341-345
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