BIOLOGICAL PROBES .3. METHODS FOR CARBON-4 AND CARBON-5 LABELING IN NICOTINAMIDE

被引：18

作者：

BRYSON, TA ^{[1
]}

DONELSON, DM ^{[1
]}

DUNLAP, RB ^{[1
]}

FISHER, RR ^{[1
]}

ELLIS, PD ^{[1
]}

机构：

[1] UNIV S CAROLINA, DEPT CHEM, COLUMBIA, SC 29208 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1976年 / 41卷 / 11期

关键词：

D O I：

10.1021/jo00873a051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The authors previously described facile pyridine syntheses in which nicotinamide can be labeled (13C, 2H, 15N) at the 1,2,3,6 and carbonyl positions and then be biosynthetically incorporated into the coenzyme NAD+. These methods were not useful for labeling the 4 position of the nicotinamide ring, the site at which biological oxidation-reduction occurs in NAD+. The present report describes an efficient, high-yield procedure for label incorporation (13C, 2H) at the 4 and the 5 position of nicotinamide.

引用

页码：2066 / 2067

页数：2

共 7 条

[1] P-31 AND C-13 NUCLEAR MAGNETIC-RESONANCE STUDIES OF NICOTINAMIDE-ADENINE DINUCLEOTIDE AND RELATED COMPOUNDS [J].