THE EFFECT OF INFUSED FAT EMULSIONS ON RETICULOENDOTHELIAL FUNCTION IN THE RABBIT

被引：6

作者：

DAVIS, SS

ILLUM, L

MULLER, R

LANDRY, F

WRIGHT, J

HARPER, G

机构：

[1] Department of Pharmaceutical Sciences, University of Nottingham, Nottingham, NG7 2RD, University Park

来源：

CLINICAL NUTRITION | 1990年 / 9卷 / 05期

关键词：

D O I：

10.1016/0261-5614(90)90034-P

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effect of the infusion of different fat emulsions (Intralipid and MCT/LCT mixtures) on the reticuloendothelial function of the rabbit has been investigated. Emulsions containing 20% dispersed triglyceride were administered over 6 h to a total of 3 g/kg body weight. The extent of blockade of the reticuloendothelial system was measured using a labelled probe in the form of technetium-99m labelled albumin microspheres. Scintigraphic and blood and organ level determinations demonstrated that all emulsions caused an impairment of reticuloendoethlial function, but this was small. © 1990.

引用

页码：260 / 265

页数：6

共 36 条

[1]

Jeejeebhoy, Total Parenteral Nutrition in the Hospital and at Home, (1983)

[2]

Judd, Freund, Deckelbaum, Human plasma lipoproteins and total parenteral nutrition with intravenous fat emulsions, Journal of Parenteral and Enteral Nutrition, 8, pp. 552-555, (1984)

[3]

Zohrab, McHattie, Jeejeebhoy, Total parenteral alimentation with lipids, Gastroenterology, 64, pp. 583-592, (1973)

[4]

Erkelens, Brunzell, Bierman, Availability of apolipoprotein CII in relation to the maximal removal capacity for an infused triglyceride emulsion in man, Metabolism, 28, pp. 495-501, (1979)

[5]

Hallberg, Studies on the elimination of exogenous lipids from the bloodstream, Acta Physiologica Scandinavica, 64, pp. 306-313, (1965)

[6]

Van Berkel, Groot, Van Tol, Interaction of the reticuloendothelia system with blood lipid and lipoprotein metabolism, The Reticuloendothelial system, A Comprehensive Treatise, Vol. 7A, Physiology, pp. 305-330, (1984)

[7]

Sailer, Berg, Stoffwechselwirkung handelsublicher und einer neuentwickelten MCT-haltigen fettemulsion, Intensivmedizin, 15, pp. 96-98, (1978)

[8]

Hailer, Wolfram, Zollner, Changes in serum lipoproteins in human following the infusion of a fat emulsion containing medium and long-chain triglycerides, European Journal of Clinical Investigation, 17, pp. 402-407, (1987)

[9]

Davis, Hansrani, The effect of surface characteristics on the phagocytosis of lipid particles, International Journal of Pharmaceutics, 23, pp. 69-77, (1985)

[10]

Davis, Hansrani, The evaluation of parenterally administered emulsion formulation, Radionuclide Imaging in Drug Research, pp. 217-241, (1982)

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