CHROMATID-TYPE ABERRATIONS INDUCED BY ALUI IN CHINESE-HAMSTER OVARY CELLS

被引：7
|
作者：
OBE, G [1 ]
JOHANNES, C [1 ]
WERTHMANN, I [1 ]
FOLLE, GA [1 ]
机构：
[1] INST INVEST BIOL CLEMENTE ESTABLE,DIV HUMAN CYTOGENET & QUANTITAT MICROSCOPY,MONTEVIDEO 11600,URUGUAY
来源：
MUTATION RESEARCH | 1993年 / 299卷 / 3-4期
关键词：
ALUI; CHROMATID-TYPE ABERRATION INDUCTION; CHO CELLS;
D O I：
10.1016/0165-1218(93)90107-O
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Treatment of CHO cells with AluI in the S-phase leads to chromatid-type aberrations whose frequencies are linearly correlated with dose. Treatment in the S-phase leads to fewer aberrations than treatment in the G1-phase, which is comparable to chromosomal aberration induction following X-irradiation in the G1- and S-phases. Treatment in the G1-phase leads to few chromatid-type interchanges, some of these may originate from DNA single-strand gaps induced by AluI in canonical structures of DNA and in DNA - RNA hybrids.
引用
收藏
页码：305 / 311
页数：7
相关论文
共 50 条
  • [1] THE RESTRICTION ENDONUCLEASE ALUI INDUCES SISTER CHROMATID EXCHANGE IN CHINESE-HAMSTER OVARY CELLS
    FOLLE, GA
    JOHANNES, C
    MECHOSO, BH
    MEDINA, II
    OBE, G
    MUTAGENESIS, 1992, 7 (04) : 291 - 294
  • [2] SISTER CHROMATID EXCHANGES AND CHROMOSOME-ABERRATIONS INDUCED BY PESTICIDE COMBINATIONS IN CHINESE-HAMSTER OVARY CELLS
    WANG, TC
    WU, CL
    LIN, JH
    TARN, CY
    LIN, SY
    BULLETIN OF THE INSTITUTE OF ZOOLOGY ACADEMIA SINICA, 1987, 26 (04): : 317 - 329
  • [3] Microphotometric scanning of chromatid gaps and breaks induced by AluI and BamHI in Chinese hamster ovary cells
    MartinezLopez, W
    Bonomi, R
    Folle, GA
    Drets, ME
    BRAZILIAN JOURNAL OF GENETICS, 1996, 19 (04): : 577 - 582
  • [4] CHROMOSOME-ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE-HAMSTER OVARY CELLS - EVALUATIONS OF 108 CHEMICALS
    GALLOWAY, SM
    ARMSTRONG, MJ
    REUBEN, C
    COLMAN, S
    BROWN, B
    CANNON, C
    BLOOM, AD
    NAKAMURA, F
    AHMED, M
    DUK, S
    RIMPO, J
    MARGOLIN, BH
    RESNICK, MA
    ANDERSON, B
    ZEIGER, E
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1987, 10 : 1 - 175
  • [5] INDUCTION OF CHROMOSOMAL-ABERRATIONS WITH THE RESTRICTION ENDONUCLEASE ALUI IN CHINESE-HAMSTER OVARY CELLS - COMPARISON OF DIFFERENT TREATMENT METHODS
    JOHANNES, C
    OBE, G
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1991, 59 (06) : 1379 - 1393
  • [6] NEOCARZINOSTATIN INDUCES CHROMOSOMAL-ABERRATIONS AND SISTER-CHROMATID EXCHANGES IN CHINESE-HAMSTER OVARY CELLS
    SCHUNCK, C
    OBE, G
    MUTAGENESIS, 1995, 10 (01) : 37 - 42
  • [7] THE LONGEVITY OF CHEMICALLY-INDUCED SISTER CHROMATID EXCHANGES IN CHINESE-HAMSTER OVARY CELLS
    MUSCARELLA, DE
    BLOOM, SE
    ENVIRONMENTAL MUTAGENESIS, 1982, 4 (06): : 647 - 655
  • [8] Interchromosomal distribution of gamma ray-induced chromatid aberrations in Chinese hamster ovary cells
    Martínez-López, W
    Porro, V
    Folle, GA
    Mendez-Acuña, L
    Savage, JRK
    Obe, G
    GENETICS AND MOLECULAR BIOLOGY, 2000, 23 (04) : 1071 - 1076
  • [9] INDUCTION OF SISTER-CHROMATID EXCHANGES BY ALUI, DNASE-I, BENZON NUCLEASE AND BLEOMYCIN IN CHINESE-HAMSTER OVARY (CHO) CELLS
    OBE, G
    SCHUNCK, C
    JOHANNES, C
    MUTATION RESEARCH, 1994, 307 (01): : 315 - 321
  • [10] UPTAKE OF THE RESTRICTION ENDONUCLEASE ALUI BY CHINESE-HAMSTER OVARY CELLS MEASURED BY FREQUENCIES OF INDUCED CHROMOSOMAL-ABERRATIONS - EFFECT OF HYPERTONIC CONCENTRATIONS OF GLYCEROL AND SORBITOL
    JOHANNES, C
    BOES, R
    OBE, G
    MUTAGENESIS, 1992, 7 (03) : 225 - 232
12345