CAMP-DEPENDENT PROTEIN-KINASE ACTIVATION MEDIATED BY BETA-3-ADRENERGIC RECEPTORS PARALLELS LIPOLYSIS IN RAT ADIPOCYTES

被引：25

作者：

LANGIN, D ^{[1
]}

EKHOLM, D ^{[1
]}

RIDDERSTRALE, M ^{[1
]}

LAFONTAN, M ^{[1
]}

BELFRAGE, P ^{[1
]}

机构：

[1] CHU RANGUEIL,INSERM,U-317,INST LOUIS BUGNARD,F-31054 TOULOUSE,FRANCE

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1135卷 / 03期

关键词：

ADRENERGIC RECEPTOR; CYCLIC-AMP-DEPENDENT PROTEIN KINASE; LIPOLYSIS; (RAT ADIPOCYTE);

D O I：

10.1016/0167-4889(92)90242-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Catecholamine-induced lipolysis is chiefly mediated through the recently characterized beta(3)-adrenergic receptor (AR) in rat adipocytes. Discrepancies between the ability of beta(3)-AR agonists to stimulate adenylyl cyclase and the resulting lipolysis were recently reported. cAMP-dependent protein kinase (A-kinase) activation induced by these agonists was compared to lipolysis. Agonist potencies were similar for A-kinase activity ratios and lipolysis. The same A-kinase activity ratio to lipolysis relationship was found for the beta(3)-AR agonists tested.

引用

页码：349 / 352

页数：4

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