PROTECTION AGAINST HOMOLOGOUS BUT NOT HETEROLOGOUS CHALLENGE INDUCED BY INACTIVATED FELINE IMMUNODEFICIENCY VIRUS-VACCINES

被引：74
|
作者：
HOSIE, MJ [1 ]
OSBORNE, R [1 ]
YAMAMOTO, JK [1 ]
NEIL, JC [1 ]
JARRETT, O [1 ]
机构：
[1] UNIV FLORIDA,COLL VET MED,DEPT COMPARAT & EXPTL PATHOL,GAINESVILLE,FL 32610
来源：
JOURNAL OF VIROLOGY | 1995年 / 69卷 / 02期
关键词：
D O I：
10.1128/JVI.69.2.1253-1255.1995
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Whale inactivated virus vaccines from the FL4 cell line protected against challenge with homologous feline immunodeficiency virus (Petaluma strain) but not against a heterologous FIV isolate (GL-8) which is distinct from the Petaluma strain in virus neutralization. Protection was associated with a type-specific neutralizing antibody response and was retained when the challenge virus was propagated in an unrelated cell line.
引用
收藏
页码：1253 / 1255
页数：3
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