ASYMMETRIC-SYNTHESIS .31. SYNTHESIS OF 2-SUBSTITUTED PIPERAZINES FROM CHIRAL NON-RACEMIC LACTAMS

被引：41

作者：

SCHANEN, V

RICHE, C

CHIARONI, A

QUIRION, JC

HUSSON, HP

机构：

[1] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,CNRS,CHIM THERAPEUT LAB,F-75270 PARIS 06,FRANCE

[2] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 16期

关键词：

ASYMMETRIC SYNTHESIS; 2-SUBSTITUTED PIPERAZINES; DIASTEREOSELECTIVE ALKYLATION OF LACTAMS;

D O I：

10.1016/S0040-4039(00)77163-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of lactam 2 from R-(-)-phenylglycinol and N-Boc glycine is described. Diastereoselective alkylation of 2 allowed the preparation of piperazine derivatives in an optically pure form.

引用

页码：2533 / 2536

页数：4

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