GASTROPROTECTIVE EFFECTS OF FRUITS OF TRIBULUS TERRESTRIS L. IN PYLORUS-LIGATED WISTAR RAT MODEL

被引：1

作者：

Ansari, Javed Akhtar ^{[1
]}

Ahmad, Md Faruque ^{[2
]}

Ahmad, Fakhruddin Ali ^{[3
]}

机构：

[1] MESCO Coll Pharm, Dept Pharmacol, Hyderabad 500006, Andhra Prades, India

[2] Jazan Univ, Fac Appl Med Sci, Dept Clin Nutr, Jazan, Saudi Arabia

[3] MOI, Tabouk, Saudi Arabia

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2013年 / 4卷 / 01期

关键词：

Ulcer; Tribulus terrestris; Pylorus ligated-induced ulcers;

D O I：

10.13040/IJPSR.0975-8232.4(1).411-14

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tribulus terrestris L. (TT; Zygophyllaceae) is employed in the folk medicine against sexual impotence, oedemas, abdominal distention and cardiovascular diseases. Gastroprotective (i.e. antiulcer and anti-secretory) potential of methanolic extract of TT fruits was evaluated in pylorus-ligated rat model of Wistar rat. The methanolic extract of TT was tested orally at the doses of 150, 300 & 600 mg/kg, on gastric ulcerations experimentally induced by pylorus ligation. Preliminary phytochemical screening of the methanol extract of TT showed the presence of alkaloids, carbohydrates, cardiac glycosides, flavonoids, saponins, tannins and proteins. The methanolic extract at the doses of 300 & 600 mg/kg produced more significant inhibition when gastric ulcerations were induced by pylorus ligation respectively. The methanol extract of the fruits of Tribulus terrestris L. possess gastroprotective i.e. antiulcer and anti-secretory effect.

引用

页码：411 / 414

页数：4

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