Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review

被引：49

作者：

Nunn, Aimie ^{[1
]}

Bath, Philip M. ^{[2
]}

Gray, Laura J. ^{[3
]}

机构：

[1] Quanticate, Stat Dept, Hitchin SG5 1LH, England

[2] Univ Nottingham, Div Clin Neurosci, Stroke Trials Unit, Nottingham NG5 1PB, England

[3] Univ Leicester, Dept Hlth Sci, Leicester LE1 7RH, Leics, England

来源：

STROKE RESEARCH AND TREATMENT | 2016年 / 2016卷

关键词：

D O I：

10.1155/2016/9482876

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Background. Historically, most acute stroke clinical trials were neutral statistically, with trials typically dichotomising ordinal scales, such as the modified Rankin Scale. Studies published before 2007 have shown that preserving the ordinal nature of these scales increased statistical power. A systematic review of trials published since 2007 was conducted to reevaluate statistical methods used and to assess whether practice has changed. Methods. A search of electronic databases identified RCTs published between January 2007 and July 2014 in acute ischaemic stroke using an ordinal dependency scale as the primary outcome. Findings. Forty-two RCTs were identified. The majority used a dichotomous analysis (25, 59.5%), eight (21.4%) retained the ordinal scale, and nine (19.0%) used another type of analysis. Conclusions. Trials published since 2007 still favoured dichotomous analyses over ordinal. Stroke trials, where appropriate, should consider retaining the ordinal nature of dependency scales.

引用

页数：7

共 27 条

[1] Statistical Analysis of the Primary Outcome in Acute Stroke Trials [J].

Bath, Philip M. W. ;

Lees, Kennedy R. ;

Schellinger, Peter D. ;

Altman, Hernan ;

Bland, Martin ;

Hogg, Cheryl ;

Howard, George ;

Saver, Jeffrey L. .

STROKE, 2012, 43 (04) :1171-1178

[2] Calculation of numbers-needed-to-treat in parallel group trials assessing ordinal outcomes: case examples from acute stroke and stroke prevention [J].

Bath, Philip M. W. ;

Hogg, Cheryl ;

Tracy, Michael ;

Pocock, Stuart .

INTERNATIONAL JOURNAL OF STROKE, 2011, 6 (06) :472-479

[3] A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke [J].

Berkhemer, O. A. ;

Fransen, P. S. S. ;

Beumer, D. ;

van den Berg, L. A. ;

Lingsma, H. F. ;

Yoo, A. J. ;

Schonewille, W. J. ;

Vos, J. A. ;

Nederkoorn, P. J. ;

Wermer, M. J. H. ;

van Walderveen, M. A. A. ;

Staals, J. ;

Hofmeijer, J. ;

van Oostayen, J. A. ;

Nijeholt, G. J. Lycklama A. ;

Boiten, J. ;

Brouwer, P. A. ;

Emmer, B. J. ;

de Bruijn, S. F. ;

van Dijk, L. C. ;

Kappelle, L. J. ;

Lo, R. H. ;

Van Dijk, E. J. ;

de Vries, J. ;

de Kort, P. L. M. ;

van Rooij, W. J. J. ;

van den Berg, J. S. P. ;

van Hasselt, B. A. A. M. ;

Aerden, L. A. M. ;

Dallinga, R. J. ;

Visser, M. C. ;

Bot, J. C. J. ;

Vroomen, P. C. ;

Eshghi, O. ;

Schreuder, T. H. C. M. L. ;

Heijboer, R. J. J. ;

Keizer, K. ;

Tielbeek, A. V. ;

den Hertog, H. M. ;

Gerrits, D. G. ;

van den Berg-Vos, R. M. ;

Karas, G. B. ;

Steyerberg, E. W. ;

Flach, H. Z. ;

Marquering, H. A. ;

Sprengers, M. E. S. ;

Jenniskens, S. F. M. ;

Beenen, L. F. M. ;

van den Berg, R. ;

Koudstaal, P. J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (01) :11-20

[4] Out of sight but not out of mind: how to search for unpublished clinical trial evidence [J].

Chan, An-Wen .

BMJ-BRITISH MEDICAL JOURNAL, 2012, 344

[5] An improved method for simple, assumption-free ordinal analysis of the modified Rankin Scale using generalized odds ratios [J].

Churilov, Leonid ;

Arnup, Sarah ;

Johns, Hayden ;

Leung, Tiffany ;

Roberts, Stuart ;

Campbell, Bruce C. V. ;

Davis, Stephen M. ;

Donnan, Geoffrey A. .

INTERNATIONAL JOURNAL OF STROKE, 2014, 9 (08) :999-1005

[6] Regression analysis of ordinal stroke clinical trial outcomes: An application to the NINDS t-PA trial [J].

DeSantis, Stacia M. ;

Lazaridis, Christos ;

Palesch, Yuko ;

Ramakrishnan, Viswanathan .

INTERNATIONAL JOURNAL OF STROKE, 2014, 9 (02) :226-231

[7] Outcome measures in acute stroke trials - A systematic review and some recommendations to improve practice [J].

Duncan, PW ;

Jorgensen, HS ;

Wade, DT .

STROKE, 2000, 31 (06) :1429-1438

[8] Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke [J].

Goyal, M. ;

Demchuk, A. M. ;

Menon, B. K. ;

Eesa, M. ;

Rempel, J. L. ;

Thornton, J. ;

Roy, D. ;

Jovin, T. G. ;

Willinsky, R. A. ;

Sapkota, B. L. ;

Dowlatshahi, D. ;

Frei, D. F. ;

Kamal, N. R. ;

Montanera, W. J. ;

Poppe, A. Y. ;

Ryckborst, K. J. ;

Silver, F. L. ;

Shuaib, A. ;

Tampieri, D. ;

Williams, D. ;

Bang, O. Y. ;

Baxter, B. W. ;

Burns, P. A. ;

Choe, H. ;

Heo, J. -H. ;

Holmstedt, C. A. ;

Jankowitz, B. ;

Kelly, M. ;

Linares, G. ;

Mandzia, J. L. ;

Shankar, J. ;

Sohn, S. -I. ;

Swartz, R. H. ;

Barber, P. A. ;

Coutts, S. B. ;

Smith, E. E. ;

Morrish, W. F. ;

Weill, A. ;

Subramaniam, S. ;

Mitha, A. P. ;

Wong, J. H. ;

Lowerison, M. W. ;

Sajobi, T. T. ;

Hill, M. D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (11) :1019-1030

[9] WHY DO ALL DRUGS WORK IN ANIMALS BUT NONE IN STROKE PATIENTS .2. NEUROPROTECTIVE THERAPY [J].

GROTTA, J .

JOURNAL OF INTERNAL MEDICINE, 1995, 237 (01) :89-94

[10] Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke [J].

Jovin, T. G. ;

Chamorro, A. ;

Cobo, E. ;

de Miquel, M. A. ;

Molina, C. A. ;

Rovira, A. ;

San Roman, L. ;

Serena, J. ;

Abilleira, S. ;

Ribo, M. ;

Millan, M. ;

Urra, X. ;

Cardona, P. ;

Lopez-Cancio, E. ;

Tomasello, A. ;

Castano, C. ;

Blasco, J. ;

Aja, L. ;

Dorado, L. ;

Quesada, H. ;

Rubiera, M. ;

Hernandez-Perez, M. ;

Goyal, M. ;

Demchuk, A. M. ;

von Kummer, R. ;

Gallofre, M. ;

Davalos, A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (24) :2296-2306

← 1 2 3 →