COMBINED MAGNETIC-FIELDS INCREASED NET CALCIUM FLUX IN BONE-CELLS

被引：81
作者：
FITZSIMMONS, RJ
RYABY, JT
MAGEE, FP
BAYLINK, DJ
机构：
[1] JERRY L PETTIS MEM VET ADM MED CTR, RES DEPT, LOMA LINDA, CA 92354 USA
[2] ORTHOLOG CORP, RES & DEV, PHOENIX, AZ 85034 USA
来源：
CALCIFIED TISSUE INTERNATIONAL | 1994年 / 55卷 / 05期
关键词：
ELECTROMAGNETIC; BONE; CALCIUM; OSTEOBLAST;
D O I：
10.1007/BF00299318
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Low energy electromagnetic fields (EMF) exhibit a large number of biological effects. A major issue to be determined is ''What is the lowest threshold of detection in which cells can respond to an EMF?'' In these studies we demonstrate that a low-amplitude combined magnetic field (CMF) which induces a maximum potential gradient of 10(-5) V/m is capable of increasing net calcium flux in human osteoblast-like cells. The increase in net calcium flux was frequency dependent, with a peak in the 15.3-16.3 Hz range with an apparent bandwidth of approximately 1 Hz. A model that characterizes the thermal noise limit indicates that nonspherical cell shape, resonant type dynamics, and signal averaging may all play a role in the transduction of low-amplitude EMF effects in biological systems.
引用
收藏
页码：376 / 380
页数：5
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