COMBINED MAGNETIC-FIELDS INCREASED NET CALCIUM FLUX IN BONE-CELLS

被引：81

作者：

FITZSIMMONS, RJ

RYABY, JT

MAGEE, FP

BAYLINK, DJ

机构：

[1] JERRY L PETTIS MEM VET ADM MED CTR, RES DEPT, LOMA LINDA, CA 92354 USA

[2] ORTHOLOG CORP, RES & DEV, PHOENIX, AZ 85034 USA

来源：

CALCIFIED TISSUE INTERNATIONAL | 1994年 / 55卷 / 05期

关键词：

ELECTROMAGNETIC; BONE; CALCIUM; OSTEOBLAST;

D O I：

10.1007/BF00299318

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low energy electromagnetic fields (EMF) exhibit a large number of biological effects. A major issue to be determined is ''What is the lowest threshold of detection in which cells can respond to an EMF?'' In these studies we demonstrate that a low-amplitude combined magnetic field (CMF) which induces a maximum potential gradient of 10(-5) V/m is capable of increasing net calcium flux in human osteoblast-like cells. The increase in net calcium flux was frequency dependent, with a peak in the 15.3-16.3 Hz range with an apparent bandwidth of approximately 1 Hz. A model that characterizes the thermal noise limit indicates that nonspherical cell shape, resonant type dynamics, and signal averaging may all play a role in the transduction of low-amplitude EMF effects in biological systems.

引用

页码：376 / 380

页数：5

共 31 条

[1] CONSTRAINTS ON BIOLOGICAL EFFECTS OF WEAK EXTREMELY-LOW-FREQUENCY ELECTROMAGNETIC-FIELDS
ADAIR, RK
[J]. PHYSICAL REVIEW A, 1991, 43 (02): : 1039 - 1048
[2] GENERATION OF ELECTRIC POTENTIALS BY BONE IN RESPONSE TO MECHANICAL STRESS
BASSETT, CAL
BECKER, RO
[J]. SCIENCE, 1962, 137 (3535) : 1063 - &
[3] BASSETT CAL, 1979, ELECTRICAL PROPERTIE, P427
[4] INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING
BERRIDGE, MJ
[J]. NATURE, 1993, 361 (6410) : 315 - 325
[5] FROM THE LANGEVIN-LORENTZ TO THE ZEEMAN MODEL OF ELECTROMAGNETIC EFFECTS ON LIGAND RECEPTOR-BINDING
BIANCO, B
CHIABRERA, A
[J]. BIOELECTROCHEMISTRY AND BIOENERGETICS, 1992, 28 (1-2): : 355 - 365
[6] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[7] LYMPHOCYTES AND LOW-FREQUENCY ELECTROMAGNETIC-FIELDS
CADOSSI, R
BERSANI, F
COSSARIZZA, A
ZUCCHINI, P
EMILIA, G
TORELLI, G
FRANCESCHI, C
[J]. FASEB JOURNAL, 1992, 6 (09) : 2667 - 2674
[8] LARMOR PRECESSION AS A MECHANISM FOR THE DETECTION OF STATIC AND ALTERNATING MAGNETIC-FIELDS
EDMONDS, DT
[J]. BIOELECTROCHEMISTRY AND BIOENERGETICS, 1993, 30 (1-3): : 3 - 12
[9] CALCITONIN ACUTELY INCREASES NET CA-45 UPTAKE AND ALTERS ALKALINE-PHOSPHATASE SPECIFIC ACTIVITY IN HUMAN OSTEOSARCOMA CELLS
FARLEY, JR
HALL, SL
HERRING, S
[J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1993, 42 (01): : 97 - 104
[10] CALCITONIN HAS DIRECT EFFECTS ON 3[H]-THYMIDINE INCORPORATION AND ALKALINE-PHOSPHATASE ACTIVITY IN HUMAN OSTEOBLAST-LINE CELLS
FARLEY, JR
WERGEDAL, JE
HALL, SL
HERRING, S
TARBAUX, NM
[J]. CALCIFIED TISSUE INTERNATIONAL, 1991, 48 (05) : 297 - 301

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