AMOXICILLIN-RESISTANT ORAL STREPTOCOCCI AND EXPERIMENTAL INFECTIVE ENDOCARDITIS IN THE RABBIT

被引：4

作者：

LONGMAN, LP ^{[1
]}

MARSH, PD ^{[1
]}

MARTIN, MV ^{[1
]}

机构：

[1] PUBL HLTH LAB SERV,CTR APPL MICROBIOL & RES,DIV PATHOL,SALISBURY SP4 0JG,WILTS,ENGLAND

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1992年 / 30卷 / 03期

关键词：

D O I：

10.1093/jac/30.3.349

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The ability of three amoxycillin-resistant strains of Streptococcus sanguis 254, 24 and 297 (MIC 40 mg/L) to cause infective endocarditis (IE) in the rabbit was investigated. These strains all produced infection in the rabbit, as did an antibiotic sensitive control strain NCTC 7864. Prophylactic amoxycillin (400 mg/kg body weight) administered one hour before bacterial challenge prevented 80% of the animals developing IE irrespective of the challenging strain. It is concluded that amoxycillin-resistant strains of S. sanguis can cause IE and that amoxycillin prophylaxis can still be effective against these bacteria. ©1992 The British Society for Antimicrobial Chemotherapy.

引用

页码：349 / 352

页数：4

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