PARTICIPATION OF PHOSPHOLIPASE-A2 IN UNCOUPLING OF RAT-LIVER MITOCHONDRIA INDUCIBLE BY LIPID-PEROXIDATION PRODUCTS

被引：0
作者：
GOGVADZE, VG
BRUETOVETSKII, NN
ZHUKOVA, AA
机构：
来源：
BIOCHEMISTRY-MOSCOW | 1990年 / 55卷 / 12期
关键词：
MITOCHONDRIA; LIPID PEROXIDATION; CALCIUM; PHOSPHOLIPASE-A2;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The uncoupling of mitochondria induced by cumene hydroperoxide (230-mu-M), as a result of the accumulation of lipid peroxidation (LPO)* products is observed only under conditions of a calcium load. The phospholipase A2 inhibitor p-bromophenacyl bromide prevents the drop in the membrane potential and release of Ca2+ ions from the mitochondria without affecting the accumulation of phospholipase A2 production.
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页码：1634 / 1637
页数：4
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