Brodalumab: an evidence-based review of its potential in the treatment of moderate-to-severe psoriasis

被引：18

作者：

Coimbra, Susana ^{[1
,2
]}

Figueiredo, Americo ^{[3
]}

Santos-Silva, Alice ^{[2
,4
]}

机构：

[1] Univ Porto, CESPU Adv Polytech & Univ Cooperat, Inst Res & Adv Training, Hlth Sci & Technol,Gandra PRD, Oporto, Portugal

[2] Univ Porto, Inst Mol & Cell Biol, IBMC, Oporto, Portugal

[3] Univ Coimbra, Hosp & Univ Ctr Coimbra CHUC, Serv Dermatol, Coimbra, Portugal

[4] Univ Porto, Fac Pharm FFUP, Biol Sci Dept, Biochem Lab, Oporto, Portugal

来源：

CORE EVIDENCE | 2014年 / 9卷

关键词：

interleukin-17; receptor; monoclonal antibody; T helper 17 pathway;

D O I：

10.2147/CE.S33940

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Advances in knowledge regarding the pathogenesis of psoriasis have allowed the development of a new class of agents known as biologic drugs. Data confirm that T helper (Th) 17 and interleukin (IL)-17 signaling has a crucial role in the pathogenesis of the disease. High levels of IL-17 and Th17-related cytokines have been reported in psoriasis, leading to the suggestion of agents targeting IL-17 as a potential therapeutic strategy in psoriasis. Brodalumab is a human monoclonal antibody that targets IL-17 receptor A, blocking the effects of IL-17A, IL-17F, and IL-17E. Data from Phase I and Phase II clinical trials indicate that brodalumab has a favorable safety and tolerability profile, with strong clinical activity, suggesting that it is a potential tool for use in the treatment of moderate-to-severe psoriasis.

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收藏

页码：89 / 97

页数：9

相关论文

共 84 条

[1] Phenotypic and functional features of human Th17 cells [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Santarlasci, Veronica ;

Maggi, Laura ;

Liotta, Francesco ;

Mazzinghi, Benedetta ;

Parente, Eliana ;

Fili, Lucia ;

Ferri, Simona ;

Frosali, Francesca ;

Giudici, Francesco ;

Romagnani, Paola ;

Parronchi, Paola ;

Tonelli, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861

[2] Heterogeneity of human effector CD4+ T cells [J].

Annunziato, Francesco ;

Romagnani, Sergio .

ARTHRITIS RESEARCH & THERAPY, 2009, 11 (06)

[3] Serum levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17 and IL-18 in patients with active psoriasis and correlation with disease severity [J].

Arican, O ;

Aral, M ;

Sasmaz, S ;

Ciragil, P .

MEDIATORS OF INFLAMMATION, 2005, (05) :273-279

[4] Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization [J].

Boehm, Beate ;

Burkhardt, Harald ;

Uebe, Steffen ;

Apel, Maria ;

Behrens, Frank ;

Reis, Andre ;

Hueffmeier, Ulrike .

ARTHRITIS RESEARCH & THERAPY, 2012, 14 (02)

[5] Foxp3+Regulatory T Cells of Psoriasis Patients Easily Differentiate into IL-17A-Producing Cells and Are Found in Lesional Skin [J].

Bovenschen, H. Jorn ;

van de Kerkhof, Peter C. ;

van Erp, Piet E. ;

Woestenenk, Rob ;

Joosten, Irma ;

Koenen, Hans J. P. M. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (09) :1853-1860

[6]

Cai YH, 2011, IMMUNITY, V35, P596, DOI 10.1016/j.immuni.2011.08.001

[7] Serum Levels of IL-17 and IL-22 Are Reduced by Etanercept, but not by Acitretin, in Patients with Psoriasis: a Randomized-Controlled Trial [J].

Caproni, M. ;

Antiga, E. ;

Melani, L. ;

Volpi, W. ;

Del Bianco, E. ;

Fabbri, P. .

JOURNAL OF CLINICAL IMMUNOLOGY, 2009, 29 (02) :210-214

[8] A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes [J].

Cargill, Michele ;

Schrodi, Steven J. ;

Chang, Monica ;

Garcia, Veronica E. ;

Brandon, Rhonda ;

Callis, Kristina P. ;

Matsunami, Nori ;

Ardlie, Kristin G. ;

Civello, Daniel ;

Catanese, Joseph J. ;

Leong, Diane U. ;

Panko, Jackie M. ;

McAllister, Linda B. ;

Hansen, Christopher B. ;

Papenfuss, Jason ;

Prescott, Stephen M. ;

White, Thomas J. ;

Leppert, Mark F. ;

Krueger, Gerald G. ;

Begovich, Ann B. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (02) :273-290

[9] Inter-Regulation of Th17 Cytokines and the IL-36 Cytokines In Vitro and In Vivo: Implications in Psoriasis Pathogenesis [J].

Carrier, Yijun ;

Ma, Hak-Ling ;

Ramon, Hilda E. ;

Napierata, Lee ;

Small, Clayton ;

O'Toole, Margot ;

Young, Deborah A. ;

Fouser, Lynette A. ;

Nickerson-Nutter, Cheryl ;

Collins, Mary ;

Dunussi-Joannopoulos, Kyri ;

Medley, Quintus G. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (12) :2428-2437

[10] A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses [J].

Chang, Seon Hee ;

Dong, Chen .

CELL RESEARCH, 2007, 17 (05) :435-440

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