RESTORATION OF SURFACE IGM-MEDIATED APOPTOSIS IN AN ANTI-IGM-RESISTANT VARIANT OF WEHI-231 LYMPHOMA-CELLS BY HS1, A PROTEIN-TYROSINE KINASE SUBSTRATE

被引：67

作者：

FUKUDA, T

KITAMURA, D

TANIUCHI, I

MAEKAWA, Y

BENHAMOU, LE

SARTHOU, P

WATANABE, T

机构：

[1] KYUSHU UNIV, MED INST BIOREGULAT, DEPT MOLEC IMMUNOL, HIGASHI KU, FUKUOKA 81282, JAPAN

[2] KYUSHU UNIV, FAC MED, DEPT INTERNAL MED 1, HIGASHI KU, FUKUOKA 81282, JAPAN

[3] INST PASTEUR, UNITE IMMUNOCHIM ANALYT, CNRS, URA 359, F-75724 PARIS 15, FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 16期

关键词：

B CELL; TYROSINE PHOSPHORYLATION; SIGNAL TRANSDUCTION; PROGRAMMED CELL DEATH;

D O I：

10.1073/pnas.92.16.7302

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The HS1 protein is one of the major substrates of non-receptor-type protein-tyrosine kinases and is phosphorylated immediately after crosslinking of the surface IgM on B cells. The mouse B-lymphoma cell line WEHI-231 is known to undergo apoptosis upon crosslinking of surface IgM by anti-IgM antibodies. Variants of WEHI-231 that were resistant to anti-IgM-induced apoptosis expressed dramatically reduced levels of HS1 protein. Expression of the human HS1 protein from an expression vector introduced into one of the variant cell lines restored the sensitivity of the cells to apoptosis induced by surface IgM crosslinking. These results suggest that HS1 protein plays a crucial role in the B-cell antigen receptor-mediated signal transduction pathway that leads to apoptosis.

引用

收藏

页码：7302 / 7306

页数：5

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