IMPACT OF MASSIVE DOSE OF VITAMIN-A GIVEN TO PRESCHOOL-CHILDREN WITH ACUTE DIARRHEA ON SUBSEQUENT RESPIRATORY AND DIARRHEAL MORBIDITY

Objective-To assess the impact of vitamin A supplementation on morbidity from acute respiratory tract infections and diarrhoea. Design-Double blind randomised placebo controlled field trial. Setting-An urban slum area in New Delhi, India. Subjects-900 children aged 12-60 months attending a local health facility for acute diarrhoea of less than seven days' duration randomly allocated to receive vitamin A 200 000 IU or placebo. Main outcome measures-Incidence and prevalence of acute lower respiratory tract infections and diarrhoea during the 90 days after termination of the enrolment diarrhoeal episode measured by twice weekly household surveillance. Results-The incidence (relative risk 1.07; 95% confidence interval 0.92 to 1.26) and average number of days spent with acute lower respiratory tract infections were similar in the vitamin A supplementation and placebo groups. Among children aged 23 months or less there was a significant reduction in the incidence of measles (relative risk 0.06; 95% confidence interval 0.01 to 0.48). The incidence of diarrhoea was also similar (relative risk 0.95; 0.86 to 1.05) in the two groups. There was a 36% reduction in the mean daily prevalence of diarrhoea associated with fever in the vitamin A supplemented children older than 23 months. Conclusions-Results were consistent with a lack of impact on acute lower respiratory tract related mortality after vitamin A supplementation noted in other trials and a possible reduction in the severity of diarrhoea.