INDUCTION OF BETA-LACTAMASES - INVITRO PHENOMENA AND CLINICAL RELEVANCE

被引：0
作者：
WIEDEMANN, B
PETER, K
机构：
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1990年 / 18卷
关键词：
CEFOTAXIME; CEFOXITIN; BACTERIAL INFECTIONS; INDUCTION; BETA-LACTAMASE; RESISTANT MUTANTS;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
An in vitro model was used to simulate the plasma concentration - time curves for cefotaxime and cefoxitin as they would appear during treatment of patients with infections due to Enterobacter cloacae and Proteus vulgaris. The data showed that the induction of the chromosomally mediated beta-lactamase took place in both bacteria but that it had little or no effect on the bacterial kill. It is concluded that treatment failures in these settings were due to the selection of resistant mutants.
引用
收藏
页码：D58 / D66
页数：9
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