KINETIC-STUDIES ON ANTHRALIN PHOTOOXIDATION

被引：20

作者：

MULLER, K ^{[1
]}

KANNER, RC ^{[1
]}

FOOTE, CS ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90024

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1990年 / 52卷 / 03期

关键词：

D O I：

10.1111/j.1751-1097.1990.tb01785.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The photooxidation of the antipsoriatic drug anthralin (1,8‐dihydroxy‐9‐anthrone) has been studied by several kinetic techniques, including direct observation of 1O2 (1Δg) luminescence at 1.27 μm. The rate of deactivation of 1O2 increases at higher pH, demonstrating that the trihydroxy‐anthracene anion is the reactive species. Direct determination of the rate constant of 1O2 deactivation (kR+kQ) in deuterated buffer systems by luminescence quenching gave a value of 3.0 times 108M−1−1 for the anion; the neutral anthrone is unreactive. The rate constant for the neutral anthrone in benzene‐d6 is 2.8 times 104 M−1 s−1 Competition experiments with tetramethylethylene in acetonitrile gave a rate constant for reaction alone (kR) of 2.1 times 108 M−1 s−1 for the anion. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：445 / 450

页数：6

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