BOVINE BABESIOSIS - FAILURE TO INDUCE INTERFERON-GAMMA PRODUCTION IN RESPONSE TO BABESIA-BOVIS ANTIGENS IN CATTLE

被引：5

作者：

ORINDA, GO

GALE, KR

WRIGHT, IG

PARRODI, F

机构：

[1] CSIRO, Division of Tropical Animal Production, Indooroopilly, QLD 4068

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1992年 / 22卷 / 03期

关键词：

BOVINE-BABESIOSIS; INTERFERON GAMMA; BABESIA-BOVIS; IMMUNE RESPONSE;

D O I：

10.1016/S0020-7519(05)80020-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The immune response to Babesia bovis infection or vaccination was evaluated by measuring antibody and interferon gamma (IFN-gamma) production to protective recombinant and crude native B. bovis antigens. Cells from vaccinated or infected cattle failed to produce detectable IFN-gamma when stimulated with B. bovis antigens in vitro. In contrast, antibody was induced by protective recombinant B. bovis antigens. These findings are consistent with the argument that immunity to B. bovis infection is correlated most strongly with humoral rather than cell-mediated immune responses.

引用

页码：395 / 398

页数：4

共 23 条

[1]

BANERJEE D P, 1977, Tropical Animal Health and Production, V9, P153, DOI 10.1007/BF02236589

[2]

BARRY D, 1985, 1985 P APPL IMM AN S

[3] AN IMPROVED ELISA FOR THE DETECTION OF ANTIBODIES AGAINST BABESIA-BOVIS USING EITHER A NATIVE OR A RECOMBINANT BABESIA-BOVIS ANTIGEN [J].