HEMODYNAMIC-EFFECTS OF ATRIAL-NATRIURETIC-FACTOR CLEARANCE RECEPTOR OCCUPANCY IN CONSCIOUS SHEEP

被引：4

作者：

PARKES, DG ^{[1
]}

COGHLAN, JP ^{[1
]}

LEWICKI, JA ^{[1
]}

SCARBOROUGH, RM ^{[1
]}

SCOGGINS, BA ^{[1
]}

机构：

[1] HOWARD FLOREY INST EXPTL PHYSIOL & MED,PARKVILLE 3052,AUSTRALIA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 11期

基金：

英国医学研究理事会;

关键词：

Atrial natriuretic factor; Clearance receptors; Hemodynamics; Sheep;

D O I：

10.1093/ajh/3.11.829

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The present study examined the hemodynamic actions of a non-guanylate cyclase linked or “clearance” atrial natriuretic factor (ANF) receptor ligand–des[Gln116Ser117Gly118Leu119Gly120] ANF 102-121 (C-ANF 4-23) –in conscious sheep. The effect of this peptide on the duration and potency of the hypotensive action of ANF (99-126) was also studied. C-ANF (4-23), infused at 400 μg/h for 2 h, reduced blood pressure, cardiac output and stroke volume, and increased total peripheral resistance slightly. These changes were similar to those previously observed with infusion of 20 μg/h ANF (99-126) in sheep. Endogenous ANF concentration increased from 28 ± 13 to 85 ± 18 pg/mL after 80 min infusion of C-ANF (4-23). The duration of hypotensive action from injection of ANF (99-126) was increased almost two-fold during infusion of C-ANF (4-23), however the hypotensive potency of ANF (99-126) was similar both prior to and during infusion of C-ANF (4-23). These studies support the concept of the metabolism of ANF via clearance receptors, suggesting that long-term hemodynamic actions of endogenous ANF may be achieved via prolonged blockade of these clearance receptors. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：829 / 832

页数：4

共 22 条

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