CHARACTERIZATION AND PHARMACOLOGICAL STUDIES OF AN OCTOPAMINE-SENSITIVE ADENYLATE-CYCLASE FROM NERVE CORD OF LOCUSTA-MIGRATORIA

被引：16

作者：

WANG, ZW ^{[1
]}

DOWNER, RGH ^{[1
]}

GOLE, JWD ^{[1
]}

ORR, GL ^{[1
]}

机构：

[1] UNIV WATERLOO, DEPT BIOL, WATERLOO N2L 3G1, ONTARIO, CANADA

来源：

ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE | 1991年 / 99卷 / 02期

关键词：

D O I：

10.3109/13813459109146962

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An octopamine-sensitive adenylate cyclase that is insensitive to stimulation by dopamine (DA) and 5-hydroxytryptamine (5-HT), was studied in a homogenized nerve cord preparation of the migratory locust, Locusta migratoria. The enzyme complex is similar to catecholamine-sensitive cyclases from mammals with respect to pH-optimum, requirement for Mg++ and GTP, and sensitivity to forskolin. The octopamine-mediated elevation of adenylate cyclase activity is antagonized by a variety of drugs with the following order of potency: mianserin > phentolamine > promethazine > gramine > cyproheptadine > cis-flupenthixol > chlorpromazine > metoclopramide.

引用

页码：189 / 193

页数：5

共 22 条

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