IG/EBP (C/EBP-GAMMA) IS A TRANSDOMINANT NEGATIVE INHIBITOR OF C/EBP FAMILY TRANSCRIPTIONAL ACTIVATORS

被引：114

作者：

COOPER, C ^{[1
]}

HENDERSON, A ^{[1
]}

ARTANDI, S ^{[1
]}

AVITAHL, N ^{[1
]}

CALAME, K ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT MICROBIOL,NEW YORK,NY 10032

来源：

NUCLEIC ACIDS RESEARCH | 1995年 / 23卷 / 21期

关键词：

D O I：

10.1093/nar/23.21.4371

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of cDNA and genomic clones shows that the murine lg/EBP (C/EBP gamma) gene encodes a small protein with a predicted molecular weight of 16.4 kDa which contains C/EBP family basic and leucine zipper domains but lacks the transcriptional activation domains present in C/EBP (C/EBP alpha)and NF-IL6 (C/EBP beta). In transfection assays Ig/EBP is neither an activator nor a repressor of transcription; however, Ig/EBP inhibits the transcriptional ability of NF-IL6 (C/EBP beta) and C/EBP (C/EBP alpha), acting as a transdominant negative regulator, Thus Ig/EBP resembles LIP, another negative regulator of the C/EBP family, in both structure and transcriptional activity, Of the three known C/EBP family inhibitors, Ig/EBP, LIP and CHOP-10, only Ig/EBP is ubiquitously expressed. Therefore, Ig/EBP may act as a general buffer for C/EBP activators in many cell types.

引用

页码：4371 / 4377

页数：7

共 50 条

[1]

Hensel G., Meichlc A., Hizenmeier K., Kroenke M., Lymphokine Res, 8, pp. 347-351, (1989)

[2]

Akira S., Kishimoto T., Immunol. Rev, 127, pp. 25-50, (1992)

[3]

Isshiki H., Akira S., Tanabe O., Makajima T., Shimamoto T., Hirano T., Tadamitsu K., Mol. Cell. Biol, 10, pp. 2757-2764, (1990)

[4]

Mukaida N.M., Shiroo M., Matsushima K., J. Immunol, 143, pp. 1366-1371, (1989)

[5]

Nishizawa M., Wakabayashi-Ito N., Nagata S., FEBS Lett, 282, pp. 95-97, (1991)

[6]

Oliviero S., Cortese R., EMBO J, 8, pp. 1145-1151, (1989)

[7]

Uchtsteiner S., Wuarin J., Schibler U., Cell, 51, pp. 963-973, (1987)

[8]

Ancone R., Gualandi G., Ciliberto G., Nucleic Acids Res, 16, pp. 3195-3207, (1988)

[9]

Poli V., Mancini F., Cortese R., Cell, 63, pp. 643-653, (1990)

[10]

Umek R., Friedman A., McKnight S., Science, 251, pp. 288-292, (1991)

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