A NEW APPROACH TO THE SYNTHESIS OF DIPEPTIDES WITH UNNATURAL AMINO-ACIDS USING ORGANOZINC CHEMISTRY

被引：20

作者：

DUNN, MJ ^{[1
]}

GOMEZ, S ^{[1
]}

JACKSON, RFW ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT CHEM,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 13期

关键词：

D O I：

10.1039/p19950001639

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dipeptides which incorporate an iodoalanine unit at either the N- or C-terminus can be converted into the corresponding organozinc reagents upon treatment with activated zinc. The C-terminal dipeptide organozinc reagents undergo palladium-catalysed reaction with electrophiles to give dipeptides incorporating non-proteinogenic amino acids without loss of stereochemical purity. The N-terminal organozinc reagents are less synthetically useful.

引用

页码：1639 / 1640

页数：2

共 13 条

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