AUTONOMIC DYSFUNCTION IN PARKINSONS-DISEASE, TESTED WITH A COMPUTERIZED METHOD USING A FINAPRES DEVICE

被引:23
作者
NETTEN, PM
DEVOS, K
HORSTINK, MWIM
HOEFNAGELS, WHL
机构
[1] UNIV NIJMEGEN HOSP,DEPT INTERNAL MED,DIV GEN INTERNAL MED,6500 HB NIJMEGEN,NETHERLANDS
[2] UNIV NIJMEGEN HOSP,DEPT GERIATR MED,6500 HB NIJMEGEN,NETHERLANDS
[3] UNIV NIJMEGEN HOSP,DEPT NEUROL,6500 HB NIJMEGEN,NETHERLANDS
关键词
AUTONOMIC DYSFUNCTION; FINAPRES; PARKINSONS DISEASE;
D O I
10.1007/BF01827468
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
AN automated program using a Finapres device and a personal computer, using a battery of five cardiovascular reflex tests has been developed. This has been used to study cardiovascular autonomic dysfunction in 23 ambulant patients with Parkinson's disease, without disabling fluctuations, and 23 age-matched healthy controls, as a screening method to detect autonomic dysfunction. In one patient only a Finapres signal of insufficient quality due to the tremor excluded subsequent analysis. Heart rate response to forced breathing was abnormal (below the fifth percentile of 124 normals) in six (26.1%) of parkinsonian patients and in one (4.3%) healthy age- and sex-matched control, to standing up four (17.4%) versus none, and to the Valsalva manoeuvre seven (30.4%) versus two (8.7%) respectively. The blood pressure response to standing up was abnormal in two (8.7%) parkinsonian patients and in none of the controls, while the response to sustained handgrip was abnormal in five (21.7%) patients versus one (4.3%) control. Autonomic dysfunction is commonly defined as an abnormal score on two or more of the five tests. Using this arbitrary definition, five patients with Parkinson's disease (=23%) had cardiovascular autonomic dysfunction, and none of the controls were abnormal.
引用
收藏
页码:85 / 89
页数:5
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