T(1221) - A NEW RECURRENT TRANSLOCATION IN ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：197

作者：

ROMANA, SP

LECONIAT, M

BERGER, R

机构：

[1] INST GENET MOLEC,INSERM,U301,F-75010 PARIS,FRANCE

[2] INST GENET MOLEC,CNRS,SDI 159541,F-75010 PARIS,FRANCE

来源：

GENES CHROMOSOMES & CANCER | 1994年 / 9卷 / 03期

关键词：

D O I：

10.1002/gcc.2870090307

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A t(12;21)(p11-p12;q22) was detected by chromosome painting in three patients with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p- abnormalities. The three leukemias had similar immunophenotypes (DR+, CD10+, CD19+). Fluorescence in situ hybridization (FISH) experiments using YAC clones from 21q21-q22 were performed to better localize the breakpoint on chromosome 21. This breakpoint was localized to 21q22.2 in one patient. Although only one case of ALL with t(12;21) has been reported previously, the present results suggest that ttl 2;2 1) is a recurrent translocation in ALL. (C) 1994 Wiley-Liss, Inc.

引用

页码：186 / 191

页数：6

共 15 条

[1] CYTOGENETIC STUDIES OF 44 T-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS [J].

BERGER, R ;

LECONIAT, M ;

VECCHIONE, D ;

DERRE, J ;

CHEN, SJ .

CANCER GENETICS AND CYTOGENETICS, 1990, 44 (01) :69-75

[2]

CARROLL AJ, 1987, BLOOD, V70, P1962

[3] SIMULTANEOUS LOCALIZATION OF COSMIDS AND CHROMOSOME R-BANDING BY FLUORESCENCE MICROSCOPY - APPLICATION TO REGIONAL MAPPING OF HUMAN CHROMOSOME-11 [J].

CHERIF, D ;

JULIER, C ;

DELATTRE, O ;

DERRE, J ;

LATHROP, GM ;

BERGER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6639-6643

[4] CONTINUUM OF OVERLAPPING CLONES SPANNING THE ENTIRE HUMAN CHROMOSOME-21Q [J].

CHUMAKOV, I ;

RIGAULT, P ;

GUILLOU, S ;

OUGEN, P ;

BILLAUT, A ;

GUASCONI, G ;

GERVY, P ;

LEGALL, I ;

SOULARUE, P ;

GRINAS, L ;

BOUGUELERET, L ;

BELLANNECHANTELOT, C ;

LACROIX, B ;

BARILLOT, E ;

GESNOUIN, P ;

POOK, S ;

VAYSSEIX, G ;

FRELAT, G ;

SCHMITZ, A ;

SAMBUCY, JL ;

BOSCH, A ;

ESTIVILL, X ;

WEISSENBACH, J ;

VIGNAL, A ;

RIETHMAN, H ;

COX, D ;

PATTERSON, D ;

GARDINER, K ;

HATTORI, M ;

SAKAKI, Y ;

ICHIKAWA, H ;

OHKI, M ;

LEPASLIER, D ;

HEILIG, R ;

ANTONARAKIS, S ;

COHEN, D .

NATURE, 1992, 359 (6394) :380-387

[5]

KRANCE RA, 1992, LEUKEMIA, V6, P251

[6] TRANSLOCATION (12 17)(P11-12 Q11-12) - A RECURRENT PRIMARY REARRANGEMENT IN ACUTE-LEUKEMIA [J].

LIU, HW ;

WAN, SK ;

CHING, LM ;

LIANG, R ;

CHAN, LC .

CANCER GENETICS AND CYTOGENETICS, 1992, 64 (01) :27-29

[7]

MITELMAN F, 1991, GUIDELIENS CANCER CY

[8]

MITELMAN F, 1991, CATALOG CHROMOSOME A, P939

[9] CHROMOSOMES IN ACUTE-LEUKEMIA [J].

PRIGOGINA, EL ;

FLEISCHMAN, EW ;

PUCHKOVA, GP ;

KULAGINA, OE ;

MAJAKOVA, SA ;

BALAKIREV, SA ;

FRENKEL, MA ;

KHVATOVA, NV ;

PETERSON, IS .

HUMAN GENETICS, 1979, 53 (01) :5-16

[10]

RAIMONDI SC, 1986, BLOOD, V68, P69

← 1 2 →