INFLUENCE OF FLUPIRTINE, A NOVEL NONOPIOID ANALGESIC AGENT ON SOMATOSENSORY EVOKED-POTENTIALS IN RATS

被引:1
作者
NAGYMAJTENYI, L [1 ]
NICKEL, B [1 ]
DESI, I [1 ]
SZELENYI, I [1 ]
机构
[1] ASTA MED AG,DEPT PHARMACOL,W-6000 FRANKFURT,GERMANY
来源
EXPERIENTIA | 1992年 / 48卷 / 10期
关键词
FLUPIRTINE; MORPHINE; NALOXONE; SOMATOSENSORY EVOKED POTENTIAL; RAT;
D O I
10.1007/BF01919149
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The effect of flupirtine, a novel nonopioid analgesic, on somatosensory evoked potentials (SEP) was investigated in anesthetized rats. Primary somatosensory potentials were evoked in the cerebral cortex by stimulation of the skin of the whiskery part of the face. Flupirtine injected i.p. dose-dependently prolonged the latency and reduced the amplitude of SEP with ID50-values of 5.4 mg/kg (2.6-9.3 mg/kg) and 7.9 mg/kg (3.9-13.8 mg/kg), respectively. This effect of flupirtine (10 mg/kg, i.p.) on the latency and the amplitude of SEP, did not change when naloxone (1 mg/kg, i.p.) was given before flupirtine. The results indicate that the analgesic flupirtine decreases the primary somatosensory evoked potential by diminishing the excitability of cortical neurons. Opioid mechanisms are not involved.
引用
收藏
页码:992 / 993
页数:2
相关论文
共 10 条
[1]   FLUPIRTINE DEPRESSES NOCICEPTIVE ACTIVITY EVOKED IN RAT THALAMUS [J].
BLEYER, H ;
CARLSSON, KH ;
ERKEL, HJ ;
JURNA, I .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 151 (02) :259-265
[2]   DEPRESSION BY FLUPIRTINE, A NOVEL ANALGESIC AGENT, OF MOTOR AND SENSORY RESPONSES OF THE NOCICEPTIVE SYSTEM IN THE RAT SPINAL-CORD [J].
CARLSSON, KH ;
JURNA, I .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 143 (01) :89-99
[3]  
JAKOVLEV V, 1985, ARZNEIMITTEL-FORSCH, V35, P30
[4]   EFFECT OF MORPHINE ON PRIMARY SOMATOSENSORY EVOKED-RESPONSES IN RAT CEREBRAL-CORTEX [J].
JURNA, I ;
SCHLUE, WR ;
TAMM, U .
NEUROPHARMACOLOGY, 1972, 11 (03) :409-&
[5]   POSSIBLE INVOLVEMENT OF NORADRENERGIC DESCENDING PAIN-MODULATING PATHWAYS IN THE MODE OF ANTINOCICEPTIVE ACTION OF FLUPIRTINE, A NOVEL NON-OPIOID ANALGESIC [J].
NICKEL, B ;
ENGEL, J ;
SZELENYI, I .
AGENTS AND ACTIONS, 1988, 23 (1-2) :112-113
[6]  
NICKEL B, 1985, ARZNEIMITTEL-FORSCH, V35-2, P1402
[7]  
SOTOMOYANO R, 1985, ARCH INT PHARMACOD T, V254, P214
[8]   MODE OF ANTINOCICEPTIVE ACTION OF FLUPIRTINE IN THE RAT [J].
SZELENYI, I ;
NICKEL, B ;
BORBE, HO ;
BRUNE, K .
BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (03) :835-842
[9]  
VAUPEL DB, 1989, EUR J PHARMACOL, V162, P447
[10]  
Zilles K, 1985, CORTEX RAT