GASTRIN-RELEASING PEPTIDE AND CHOLECYSTOKININ IN THE REGULATION OF EXOCRINE PANCREATIC-SECRETION IN DOGS

被引：1

作者：

NUSTEDE, R ^{[1
]}

SCHMIDT, WE ^{[1
]}

LOHMANN, C ^{[1
]}

KOHLER, H ^{[1
]}

SCHLEMMINGER, R ^{[1
]}

SCHAFMAYER, A ^{[1
]}

机构：

[1] UNIV GOTTINGEN,DEPT MED,DIV GASTROENTEROL,W-3400 GOTTINGEN,GERMANY

来源：

DIGESTION | 1993年 / 54卷 / 02期

关键词：

CHOLECYSTOKININ; GRP; PANCREATIC SECRETION; CHOLECYSTOKININ RECEPTOR ANTAGONIST;

D O I：

10.1159/000201017

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Exocrine pancreatic secretion in conscious dogs is significantly stimulated bv the intravenous application of small doses of gastrin-releasing peptide (GRP; 30 pmol X kg-1 X h-1). There is no increase of the GRP concentrations in peripheral blood which is also the case under physiological postprandial conditions. There is also no increase in the peripheral cholecystokinin (CCK) concentrations, in contrast to previous reports. Nevertheless other CCK-related mechanisms may play an important role, since the administration of the highly specific CCK receptor antagonist MK-329 causes a marked reduction of the GRP-induced exocrine panceratic secretion.

引用

页码：79 / 83

页数：5

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