Deficiency of C1 inhibitor resulting in episodes of angioedema causes significant morbidity and mortality in affected patients, yet often goes undiagnosed for years. As biochemical understanding of the disorder has improved, competing theories for the pathophysiologic mechanism of angioedema have emerged. Further, existing therapeutic interventions have been refined by experience and newer modalities currently available in Europe may soon become available in the United States.
机构:
Univ Milan, Dipartimento Sci Clin L Sacco, Osped Luigi Sacco, I-20157 Milan, ItalyUniv Milan, Dipartimento Sci Clin L Sacco, Osped Luigi Sacco, I-20157 Milan, Italy
机构:
Univ Milan, Osped L Sacco, Dipartimento Sci Clin Luigi Sacco, Milan, ItalyUniv Milan, Osped L Sacco, Dipartimento Sci Clin Luigi Sacco, Milan, Italy