BIOSYNTHESIS OF THE NEUROTOXIN DOMOIC ACID BY THE MARINE DIATOM NITZSCHIA-PUNGENS FORMA MULTISERIES, DETERMINED WITH [C-13]-LABELED PRECURSORS AND NUCLEAR-MAGNETIC-RESONANCE

被引：34

作者：

DOUGLAS, DJ ^{[1
]}

RAMSEY, UP ^{[1
]}

WALTER, JA ^{[1
]}

WRIGHT, JLC ^{[1
]}

机构：

[1] NATL RES COUNCIL CANADA,ATLANTIC REG LAB,INST MARINE BIOSCI,1411 OXFORD ST,HALIFAX B3H 3Z1,NS,CANADA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 09期

关键词：

D O I：

10.1039/c39920000714

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Labelling experiments with [1-C-13]acetate and [1,2-C-13]acetate provide evidence that the neurotoxin domoic acid, produced by the diatom Nitzschia pungens, is derived by the novel condensation of a geranyl unit with an activated citric acid cycle derivative and subsequent cyclisation to form a proline ring system.

引用

页码：714 / 716

页数：3

共 9 条

[1]

[Anonymous], KAINIC ACID TOOL NEU

[2] PENNATE DIATOM NITZSCHIA-PUNGENS AS THE PRIMARY SOURCE OF DOMOIC ACID, A TOXIN IN SHELLFISH FROM EASTERN PRINCE EDWARD ISLAND, CANADA [J].

BATES, SS ;

BIRD, CJ ;

DEFREITAS, ASW ;

FOXALL, R ;

GILGAN, M ;

HANIC, LA ;

JOHNSON, GR ;

MCCULLOCH, AW ;

ODENSE, P ;

POCKLINGTON, R ;

QUILLIAM, MA ;

SIM, PG ;

SMITH, JC ;

RAO, DVS ;

TODD, ECD ;

WALTER, JA ;

WRIGHT, JLC .

CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES, 1989, 46 (07) :1203-1215

[3] PRODUCTION OF DOMOIC ACID, A NEUROTOXIC AMINO-ACID, BY AN AXENIC CULTURE OF THE MARINE DIATOM NITZSCHIA-PUNGENS F-MULTISERIES HASLE [J].

DOUGLAS, DJ ;

BATES, SS .

CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES, 1992, 49 (01) :85-90

[4] Glutamate agonists from marine algae [J].

Laycock, M. V. ;

de Freitas, A. S. W. ;

Wright, J. L. C. .

JOURNAL OF APPLIED PHYCOLOGY, 1989, 1 (02) :113-122

[5]

LOWENSTEIN JM, 1967, METABOLIC PATHWAYS, V1, P147

[6] BIOSYNTHESIS OF CAERULOMYCIN-A IN STREPTOMYCES-CAERULEUS - INCORPORATION OF C-14-LABELED AND C-13-LABELED PRECURSORS AND ANALYSES OF LABELING PATTERNS BY C-13 NMR [J].

MCINNES, AG ;

SMITH, DG ;

WALTER, JA ;

VINING, LC ;

WRIGHT, JLC .

CANADIAN JOURNAL OF CHEMISTRY, 1979, 57 (24) :3200-3204

[7]

WALTER JA, 1992, IN PRESS CAN J CHEM

[8]

WORK TM, 1992, IN PRESS 5TH P INT C

[9] IDENTIFICATION OF DOMOIC ACID, A NEUROEXCITATORY AMINO-ACID, IN TOXIC MUSSELS FROM EASTERN PRINCE-EDWARD-ISLAND [J].

WRIGHT, JLC ;

BOYD, RK ;

DEFREITAS, ASW ;

FALK, M ;

FOXALL, RA ;

JAMIESON, WD ;

LAYCOCK, MV ;

MCCULLOCH, AW ;

MCINNES, AG ;

ODENSE, P ;

PATHAK, VP ;

QUILLIAM, MA ;

RAGAN, MA ;

SIM, PG ;

THIBAULT, P ;

WALTER, JA ;

GILGAN, M ;

RICHARD, DJA ;

DEWAR, D .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1989, 67 (03) :481-490

← 1 →