BIOSYNTHESIS OF THE NEUROTOXIN DOMOIC ACID BY THE MARINE DIATOM NITZSCHIA-PUNGENS FORMA MULTISERIES, DETERMINED WITH [C-13]-LABELED PRECURSORS AND NUCLEAR-MAGNETIC-RESONANCE

被引：34

作者：

DOUGLAS, DJ ^{[1
]}

RAMSEY, UP ^{[1
]}

WALTER, JA ^{[1
]}

WRIGHT, JLC ^{[1
]}

机构：

[1] NATL RES COUNCIL CANADA,ATLANTIC REG LAB,INST MARINE BIOSCI,1411 OXFORD ST,HALIFAX B3H 3Z1,NS,CANADA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 09期

关键词：

D O I：

10.1039/c39920000714

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Labelling experiments with [1-C-13]acetate and [1,2-C-13]acetate provide evidence that the neurotoxin domoic acid, produced by the diatom Nitzschia pungens, is derived by the novel condensation of a geranyl unit with an activated citric acid cycle derivative and subsequent cyclisation to form a proline ring system.

引用

页码：714 / 716

页数：3

共 9 条

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