Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity

被引：98
作者：
Vinketova, Kameliya [1 ]
Mourdjeva, Milena [1 ]
Oreshkova, Tsvetelina [1 ]
机构：
[1] Bulgarian Acad Sci, Inst Biol & Immunol Reprod, Dept Mol Immunol, 73 Tsarigradsko Shose, BU-1113 Sofia, Bulgaria
来源：
JOURNAL OF PREGNANCY | 2016年 / 2016卷
关键词：
D O I：
10.1155/2016/8689436
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The human decidua is a specialized tissue characterized by embryo-receptive properties. It is formed during the secretory phase of menstrual cycle from uterine mucosa termed endometrium. The decidua is composed of glands, immune cells, blood and lymph vessels, and decidual stromal cells (DSCs). In the process of decidualization, which is controlled by oestrogen and progesterone, DSCs acquire specific functions related to recognition, selection, and acceptance of the allogeneic embryo, as well as to development of maternal immune tolerance. In this review we discuss the relationship between the decidualization of DSCs and pathological obstetrical and gynaecological conditions. Moreover, the critical influence of DSCs on local immune cells populations as well as their relationship to the onset and maintenance of immune tolerance is described.
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