INTERLEUKIN-1-BETA, INTERLEUKIN-6, EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR-ALPHA ARE ELEVATED IN THE BRAIN FROM PARKINSONIAN-PATIENTS

被引：729

作者：

MOGI, M

HARADA, M

KONDO, T

RIEDERER, P

INAGAKI, H

MINAMI, M

NAGATSU, T

机构：

[1] FUJITA HLTH UNIV,SCH MED,INST COMPREHENS MED SCI,TOYOAKE,AICHI 47011,JAPAN

[2] UNIV WURZBURG,DEPT PSYCHIAT,W-8700 WURZBURG,GERMANY

[3] NIPPON MED COLL,DEPT HYG & PUBL HLTH,TOKYO,JAPAN

[4] JUNTENDO UNIV,SCH MED,DEPT NEUROL,TOKYO 113,JAPAN

[5] MATSUMOTO DENT COLL,DEPT ORAL BIOCHEM,SHIOJIRI,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 180卷 / 02期

关键词：

INTERLEUKIN-1-BETA; INTERLEUKIN-6; EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR-ALPHA; PARKINSONS DISEASE; BRAIN;

D O I：

10.1016/0304-3940(94)90508-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin (IL)-1 beta, IL-6, epidermal growth factor (EGF), and transforming growth factor-alpha (TGF-alpha) were measured for the first time in the brain (caudate nucleus, putamen and cerebral cortex) from control and parkinsonian patients by highly sensitive sandwich enzyme immunoassays. The concentrations of IL-1 beta, IL-6, EGF, and TGF-alpha in the dopaminergic, striatal regions were significantly higher in parkinsonian patients than those in controls, whereas those in the cerebral cortex did not show significant differences between parkinsonian and control subjects. Since these cytokines and growth factors may play important roles as neurotrophic factors in the brain, the present results suggest that they may be produced as compensatory responses in the nigrostriatal dopaminergic regions in Parkinson's disease, and may be related, at least in part, to the process of neurodegeneration in Parkinson's disease.

引用

页码：147 / 150

页数：4

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