AN EVALUATION OF 55 COMMERCIAL PLANT-EXTRACTS IN THE AMES MUTAGENICITY TEST

被引：0
作者：
SCHIMMER, O
KRUGER, A
PAULINI, H
HAEFELE, F
机构：
来源：
PHARMAZIE | 1994年 / 49卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
55 commercial phytopharmaceuticals (extracts and tinctures) from 44 plant species were evaluated for mutagenic potential in the Salmonella/mammalian microsome mutagenicity test (Ames assay), utilizing tester strains TA98 and TA100 of Salmonella typhimurium with and without S9 mix from induced rat liver microsomes. Weak activities were detected after exposure of the bacteria to Alchemillae tinctura, Centaurii extractum, Hippocastani extractum and Myrtilli extractum. Moderate effects were observed with Crataegi extractum, Echinaceae angustifoliae extractum, Hyperici tinctura, Rutae tinctura and Trifolii fibrini extractum and tinctura. Quercetin was detected by TLC in all extracts with mutagenic activity except in Echinaceae angustifoliae and Centaurii extractum. From this study and earlier results we suggest that quercetin is possibly the main mutagenic principle in the following phytopharmaceuticals: Alchemillae tinctura, Crataegi extractum, Hippocastani extractum, Hyperici tinctura, Myrtilli extractum, Trifolii fibrini extractum and Trifolii fibrini tinctura.
引用
收藏
页码：448 / 451
页数：4
相关论文
共 22 条
  • [1] FORMATION OF GENOTOXIC METABOLITES FROM ANTHRAQUINONE GLYCOSIDES, PRESENT IN RUBIA-TINCTORUM L
    BLOMEKE, B
    POGINSKY, B
    SCHMUTTE, C
    MARQUARDT, H
    WESTENDORF, J
    [J]. MUTATION RESEARCH, 1992, 265 (02): : 263 - 272
  • [2] MUTAGENIC POTENCIES OF MEDICINAL-PLANTS SCREENED IN THE AMES TEST
    BRESOLIN, S
    VARGAS, VMF
    [J]. PHYTOTHERAPY RESEARCH, 1993, 7 (03) : 260 - 262
  • [3] MUTAGENICITY OF PLANT FLAVONOLS IN THE SALMONELLA-MAMMALIAN MICROSOME TEST - ACTIVATION OF FLAVONOL GLYCOSIDES BY MIXED GLYCOSIDASES FROM RAT CECAL BACTERIA AND OTHER SOURCES
    BROWN, JP
    DIETRICH, PS
    [J]. MUTATION RESEARCH, 1979, 66 (03): : 223 - 240
  • [4] GOGGELMANN W, 1986, GENETIC TOXICOLOGY D, V63
  • [5] HAEFELE F, 1988, THESIS U ERLANGEN NU
  • [6] COMPARATIVE MUTAGENESIS OF PLANT FLAVONOIDS IN MICROBIAL SYSTEMS
    HARDIGREE, AA
    EPLER, JL
    [J]. MUTATION RESEARCH, 1978, 58 (2-3): : 231 - 239
  • [7] KRUGER A, 1991, THESIS U ERLANGEN NU
  • [8] LEE HK, 1987, MUTAT RES, V192, P99
  • [9] REVISED METHODS FOR THE SALMONELLA MUTAGENICITY TEST
    MARON, DM
    AMES, BN
    [J]. MUTATION RESEARCH, 1983, 113 (3-4): : 173 - 215
  • [10] MUTAGENICITY OF HYDROLYSATES OF CITRUS-FRUIT JUICES
    MAZAKI, M
    ISHII, T
    UYETA, M
    [J]. MUTATION RESEARCH, 1982, 101 (04): : 283 - 291
123