CLONING AND SEQUENCE-ANALYSIS OF A MURINE CDNA-ENCODING GLUTAMATE-DECARBOXYLASE (GAD65)

被引：36
作者：
LEE, DS [1 ]
TIAN, JD [1 ]
PHAN, T [1 ]
KAUFMAN, DL [1 ]
机构：
[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT PSYCHIAT & BIOBEHAV SCI,760 WESTWOOD PLAZA,LOS ANGELES,CA 90024
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1216卷 / 01期
关键词：
GLUTAMATE DECARBOXYLASE; CDNA; CLONING; GAD; GABA; DIABETES; (NOD MOUSE);
D O I：
10.1016/0167-4781(93)90056-J
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report the cloning and cDNA sequence of murine GAD65. Murine GAD65 is comprised of 585 amino acids and shares a high degree of homology with human and rat GAD65, with most divergences occurring near their amino-termini. The murine GAD65 sequence will allow evaluation of the role of this gene in murine neurogenetic and autoimmune diseases.
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页码：157 / 160
页数：4
相关论文
共 36 条
[1]   64000 MR AUTOANTIBODIES AS PREDICTORS OF INSULIN-DEPENDENT DIABETES [J].
ATKINSON, MA ;
MACLAREN, NK ;
SCHARP, DW ;
LACY, PE ;
RILEY, WJ .
LANCET, 1990, 335 (8702) :1357-1360
[2]   RESPONSE OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS TO GLUTAMATE-DECARBOXYLASE IN INSULIN-DEPENDENT DIABETES [J].
ATKINSON, MA ;
KAUFMAN, DL ;
CAMPBELL, L ;
GIBBS, KA ;
SHAH, SC ;
BU, DF ;
ERLANDER, MG ;
TOBIN, AJ ;
MACLAREN, NK .
LANCET, 1992, 339 (8791) :458-459
[3]  
ATKINSON MA, 1990, SCI AM, V262, P61
[4]   AUTOANTIBODIES IN NEWLY DIAGNOSED DIABETIC CHILDREN IMMUNOPRECIPITATE HUMAN PANCREATIC-ISLET CELL-PROTEINS [J].
BAEKKESKOV, S ;
NIELSEN, JH ;
MARNER, B ;
BILDE, T ;
LUDVIGSSON, J ;
LERNMARK, A .
NATURE, 1982, 298 (5870) :167-169
[5]   IDENTIFICATION OF THE 64K AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES AS THE GABA-SYNTHESIZING ENZYME GLUTAMIC-ACID DECARBOXYLASE [J].
BAEKKESKOV, S ;
AANSTOOT, HJ ;
CHRISTGAU, S ;
REETZ, A ;
SOLIMENA, M ;
CASCALHO, M ;
FOLLI, F ;
RICHTEROLESEN, H ;
CAMILLI, PD .
NATURE, 1990, 347 (6289) :151-156
[6]   2 HUMAN GLUTAMATE DECARBOXYLASES, 65-KDA GAD AND 67-KDA GAD, ARE EACH ENCODED BY A SINGLE GENE [J].
BU, DF ;
ERLANDER, MG ;
HITZ, BC ;
TILLAKARATNE, NJK ;
KAUFMAN, DL ;
WAGNERMCPHERSON, CB ;
EVANS, GA ;
TOBIN, AJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2115-2119
[7]   TYPE-I DIABETES - A CHRONIC AUTOIMMUNE-DISEASE OF HUMAN, MOUSE, AND RAT [J].
CASTANO, L ;
EISENBARTH, GS .
ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 :647-679
[8]   MEMBRANE ANCHORING OF THE AUTOANTIGEN-GAD(65) TO MICROVESICLES IN PANCREATIC BETA-CELLS BY PALMITOYLATION IN THE NH2-TERMINAL DOMAIN [J].
CHRISTGAU, S ;
AANSTOOT, HJ ;
SCHIERBECK, H ;
BEGLEY, K ;
TULLIN, S ;
HEJNAES, K ;
BAEKKESKOV, S .
JOURNAL OF CELL BIOLOGY, 1992, 118 (02) :309-320
[9]  
EDGINGTON SM, 1992, BIO-TECHNOL, V10, P641
[10]   THE STRUCTURAL AND FUNCTIONAL-HETEROGENEITY OF GLUTAMIC-ACID DECARBOXYLASE - A REVIEW [J].
ERLANDER, MG ;
TOBIN, AJ .
NEUROCHEMICAL RESEARCH, 1991, 16 (03) :215-226
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