Circulating mesenchymal stem cells and their clinical implications

被引：120
|
作者：
Xu, Liangliang [1 ]
Li, Gang [1 ,2 ,3 ,4 ]
机构：
[1] Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Sch Biomed Sci, Minist Educ, Key Lab Regenerat Med, Hong Kong, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Stem Cells & Regenerat Med Lab, Shatin, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Fac Med, Lui Che Woo Inst Innovat Med, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF ORTHOPAEDIC TRANSLATION | 2014年 / 2卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Circulating MSCs; Allogenic MSCs; Cell therapy;
D O I：
10.1016/j.jot.2013.11.002
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Circulating mesenchymal stem cells (MSCs) is a new cell source for tissue regeneration and tissue engineering. The characteristics of circulating MSCs are similar to those of bone marrow-derived MSCs (BM-MSCs), but they exist at a very low level in healthy individuals. It has been demonstrated that MSCs are able to migrate to the sites of injury and that they have some distinct genetic profiles compared to BM-MSCs. The current review summaries the basic knowledge of circulating MSCs and their potential clinical applications, such as mobilizing the BM-MSCs into circulation for therapy. The application of MSCs to cure a broad spectrum of diseases is promising, such as spinal cord injury, cardiovascular repair, bone and cartilage repair. The current review also discusses the issues of using of allogeneic MSCs for clinical therapy. Copyright (C) 2014, The Authors. Published by Elsevier (Singapore) Pte Ltd. This is an open access article under the CC BY-NC-ND license
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页码：1 / 7
页数：7
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