INVIVO BRAIN DIALYSIS OF NEUROTRANSMITTERS

被引：155

作者：

DICHIARA, G

机构：

[1] University of Cagliari, 09100 Cagliari

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1990年 / 11卷 / 03期

关键词：

(3α-tropanyl)-1H-indole-3-carboxylic acid ester; 1αH3α-(5αH-tropan-3-yl)-3,5-dichiorobenzoate; ICS205930; MDL72222; R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol; SCH23390;

D O I：

10.1016/0165-6147(90)90197-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Centrally acting drugs interfere with the function of central neurotransmitter systems. This often requires intact neuronal connections and is therefore best studied in vivo. Here, Gaetano Di Chiara describes the technique of brain dialysis, which permits direct in-vivo sampling of neurotransmitters and their metabolites in the brain extracellular fluid. This technique is now providing insight correlating the interaction of drugs with neurotransmission in specific brain areas with their effects on behaviour. © 1990.

引用

收藏

页码：116 / 121

页数：6

相关论文

共 39 条

[1] TYROSINE - EFFECTS ON CATECHOLAMINE RELEASE [J].

ACWORTH, IN ;

DURING, MJ ;

WURTMAN, RJ .

BRAIN RESEARCH BULLETIN, 1988, 21 (03) :473-477

[2] DETERMINATION OF BRAIN INTERSTITIAL CONCENTRATIONS BY MICRODIALYSIS [J].

BENVENISTE, H ;

HANSEN, AJ ;

OTTOSEN, NS .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (06) :1741-1750

[3]

BENVENISTE H, 1987, J NEUROCHEM, V51, P683

[4] CALCIUM-DEPENDENT, TETRODOTOXIN-SENSITIVE STIMULATION OF CORTICAL SEROTONIN RELEASE AFTER A TRYPTOPHAN LOAD [J].

CARBONI, E ;

CADONI, C ;

TANDA, GL ;

DICHIARA, G .

JOURNAL OF NEUROCHEMISTRY, 1989, 53 (03) :976-978

[5] SEROTONIN RELEASE ESTIMATED BY TRANSCORTICAL DIALYSIS IN FREELY-MOVING RATS [J].

CARBONI, E ;

DICHIARA, G .

NEUROSCIENCE, 1989, 32 (03) :637-645

[6] AMPHETAMINE, COCAINE, PHENCYCLIDINE AND NOMIFENSINE INCREASE EXTRACELLULAR DOPAMINE CONCENTRATIONS PREFERENTIALLY IN THE NUCLEUS ACCUMBENS OF FREELY MOVING RATS [J].

CARBONI, E ;

IMPERATO, A ;

PEREZZANI, L ;

DICHIARA, G .

NEUROSCIENCE, 1989, 28 (03) :653-661

[7] EXTRACELLULAR DOPAMINE IN RAT STRIATUM FOLLOWING UPTAKE INHIBITION BY COCAINE, NOMIFENSINE AND BENZTROPINE [J].

CHURCH, WH ;

JUSTICE, JB ;

BYRD, LD .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 139 (03) :345-348

[8] DETECTING BEHAVIORALLY RELEVANT CHANGES IN EXTRACELLULAR DOPAMINE WITH MICRODIALYSIS [J].

CHURCH, WH ;

JUSTICE, JB ;

NEILL, DB .

BRAIN RESEARCH, 1987, 412 (02) :397-399

[9]

CONSOLO S, 1987, J PHARMACOL EXP THER, V242, P300

[10] DETERMINATION OF ENDOGENOUS ACETYLCHOLINE-RELEASE IN FREELY MOVING RATS BY TRANSSTRIATAL DIALYSIS COUPLED TO A RADIOENZYMATIC ASSAY - EFFECT OF DRUGS [J].

CONSOLO, S ;

WU, CF ;

FIORENTINI, F ;

LADINSKY, H ;

VEZZANI, A .

JOURNAL OF NEUROCHEMISTRY, 1987, 48 (05) :1459-1465

← 1 2 3 4 →