Polymyxin-B-immobilized-fiber column hemoperfusion with oseltamivir treatment for ARDS due to influenza H1N1/09

被引：12

作者：

Binh, Nguyen Gia ^{[1
]}

Manabe, Toshie ^{[2
,3
]}

Co, Dao Xuan ^{[1
]}

Tuan, Nguyen Dang ^{[1
]}

Thach, Pham The ^{[1
]}

Kudo, Koichiro ^{[2
,4
,5
]}

机构：

[1] Bach Mai Hosp, Intens Care Unit, Hanoi, Vietnam

[2] Waseda Univ, Org Asian Study, Shinjuku Ku, 1-21-1 Nishi-waseda, Tokyo 1690051, Japan

[3] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Pulm Med, Tsukuba, Ibaraki, Japan

[4] Fukujuji Hosp, Dept Pulm Med, Tokyo, Japan

[5] Koto Hosp, Dept Pulm Med & Infect Control, Tokyo, Japan

来源：

RESPIROLOGY CASE REPORTS | 2015年 / 3卷 / 02期

基金：

日本学术振兴会;

关键词：

Acute respiratory distress syndrome (ARDS); influenza; oseltamivir; PaO2/FiO(2); polymyxin-B-immobilized fiber column (PMX-DHP);

D O I：

10.1002/rcr2.100

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Acute respiratory distress syndrome (ARDS) is one of the severe complications of influenza H1N1/09 infection, resulting in high mortality. Effective treatment strategies for ARDS are needed. This report presents two cases of ARDS due to influenza in Vietnam. Both cases were similar in terms of starting symptoms, the rapid progression to ARDS, and the treatment strategy, direct hemoperfusion with a polymyxin-B-immobilized fiber column (PMX-DHP) and oseltamivir. However, the clinical course of disease and the outcomes were different. For case 1, treatment was initiated on day 4 following the onset of hypoxemia due to ARDS. Symptoms improved rapidly after treatment and the patient was discharged on day 12. For case 2, treatment was initiated on day 9 after the onset of symptoms. Despite intensive therapy, the patient died on day 18. In conclusion, treatment with PMX-DHP and oseltamivir is effective on ARDS due to influenza but only if initiated early.

引用

页码：57 / 60

页数：4

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