HEPATITIS-B VIRUS VARIANTS IN CARRIERS WITH HEMATOLOGIC MALIGNANCIES IN WHOM FULMINANT HEPATIC-FAILURE DEVELOPS AFTER CHEMOTHERAPY

被引：1

作者：

FUJISE, K ^{[1
]}

NAITO, Y ^{[1
]}

NAKAMURA, M ^{[1
]}

NIIYA, M ^{[1
]}

SATO, S ^{[1
]}

KATAYAMA, T ^{[1
]}

WATANABE, R ^{[1
]}

HOSHINA, S ^{[1
]}

KONO, M ^{[1
]}

MACHIDA, K ^{[1
]}

机构：

[1] JIKEI UNIV, SCH MED, DEPT LAB MED, MINATO KU, TOKYO 105, JAPAN

来源：

INTERNATIONAL HEPATOLOGY COMMUNICATIONS | 1995年 / 4卷 / 03期

关键词：

HEPATITIS B VIRUS; HEMATOLOGIC DISEASES; CHEMOTHERAPY; HEPATIC FAILURE; MUTATION;

D O I：

10.1016/0928-4346(95)00237-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Three patients who were carriers of hepatitis B virus (HBV) and had hematologic malignancies, experienced fulminant hepatic failure after withdrawal of chemotherapy. Before treatment, each patient had inactive HBV infection with undetectable viral DNA polymerase; two patients were negative for hepatitis B e antigen. After chemotherapy, DNA polymerase increased and HBV variants with mutations in the precore region prevailed in their sera. These results implicate precore mutants thriving after chemotherapy and restored immune responses of patients in the pathogenesis of severe hepatic failure.

引用

页码：142 / 148

页数：7

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