SCRATCHING THE SURFACE WITH THE PH DOMAIN

被引：59
作者：
FERGUSON, KM
LEMMON, MA
SIGLER, PB
SCHLESSINGER, J
机构：
[1] YALE UNIV,HOWARD HUGHES MED INST,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06510
[2] NYU,MED CTR,DEPT PHARMACOL,NEW YORK,NY 10016
来源：
NATURE STRUCTURAL BIOLOGY | 1995年 / 2卷 / 09期
关键词：
D O I：
10.1038/nsb0995-715
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pleckstrin homology (PH) domains bind to membrane surfaces, and inositol phospholipids appear to form part of the binding sites. Recent structural studies provide a model for PH domain anchoring to inositol phospholipids that will open new avenues for functional investigation.
引用
收藏
页码：715 / 718
页数：4
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