METABOLISM OF HIGHLY PERSISTENT PCB CONGENER, 2,4,5,2',4',5'-HEXACHLOROBIPHENYL, BY HUMAN CYP2B6

被引：48
作者：
ARIYOSHI, N
OGURI, K
KOGA, N
YOSHIMURA, H
FUNAE, Y
机构：
[1] KYUSHU UNIV 62,FAC PHARMACEUT SCI,HIGASHI KU,FUKUOKA 81282,JAPAN
[2] NAKAMURA GAKUEN UNIV,DEPT FOOD & NUTR,JOHNAN KU,FUKUOKA 81401,JAPAN
[3] OSAKA CITY UNIV,SCH MED,CHEM LAB,ABENO KU,OSAKA 545,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 212卷 / 02期
关键词：
D O I：
10.1006/bbrc.1995.1991
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metabolism of 2,4,5,2',4',5'-hexachlorobiphenyl was studied with cDNA-expressed human P450 2B isoform, CYP2B6. 3-Hydroxy-2,4,5,2',4',5'-hexachlorobiphenyl was identified as a major metabolite, and the formation activity was compared with that of dog CYP2B11 and guinea pig P450(GP-1). The activity of 3-hydroxylation was comparable with that of P450(GP-1), but one-tenth of CYP2B11. These results indicate that P450 2B in humans as well as other animal species can metabolize 2,4,5,2',4',5'-hexachlorobiphenyl, and the reason why this PCB congener remained most abundantly in human bodies is discussed. (C) 1995 Academic Press, Inc.
引用
收藏
页码：455 / 460
页数：6
相关论文
共 19 条
[1]   METABOLISM OF 2,4,5,2',4',5'-HEXACHLOROBIPHENYL WITH LIVER-MICROSOMES OF PHENOBARBITAL-TREATED DOG - THE POSSIBLE FORMATION OF PCB 2,3-ARENE OXIDE INTERMEDIATE [J].
ARIYOSHI, N ;
KOGA, N ;
OGURI, K ;
YOSHIMURA, H .
XENOBIOTICA, 1992, 22 (11) :1275-1290
[2]   PURIFICATION AND CHARACTERIZATION OF THE DOG HEPATIC CYTOCHROME-P-450 ISOZYME RESPONSIBLE FOR THE METABOLISM OF 2,2',4,4',5,5'-HEXACHLOROBIPHENYL [J].
DUIGNAN, DB ;
SIPES, IG ;
LEONARD, TB ;
HALPERT, JR .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1987, 255 (02) :290-303
[3]   METABOLISM INVITRO OF 3,4,3',4'-TETRACHLOROBIPHENYL AND 2,5,2',5'-TETRACHLOROBIPHENYL BY RAT-LIVER MICROSOMES AND HIGHLY PURIFIED CYTOCHROME-P-450 [J].
ISHIDA, C ;
KOGA, N ;
HANIOKA, N ;
SAEKI, HK ;
YOSHIMURA, H .
JOURNAL OF PHARMACOBIO-DYNAMICS, 1991, 14 (05) :276-284
[4]  
JANSSON I, 1975, MOL PHARMACOL, V11, P450
[5]   ESCHERICHIA-COLI EXPRESSION AND CHARACTERIZATION OF CYTOCHROMES P450 2B11, 2B1, AND 2B5 [J].
JOHN, GH ;
HASLER, JA ;
HE, YA ;
HALPERT, JR .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1994, 314 (02) :367-375
[6]   EXPOSED AND CONTROL HUMAN BLOOD-LEVELS FROM GUAM AND BINGHAMTON WORKERS AND YUSHO PATIENTS [J].
MASUDA, Y ;
SCHECTER, A .
CHEMOSPHERE, 1992, 25 (7-10) :1091-1094
[7]   THE ELIMINATION AND ESTIMATED HALF-LIVES OF SPECIFIC POLYCHLORINATED BIPHENYL CONGENERS FROM THE BLOOD OF FEMALE MONKEYS AFTER DISCONTINUATION OF DAILY DOSING WITH AROCLOR(R)-1254 [J].
MES, J ;
ARNOLD, DL ;
BRYCE, F .
CHEMOSPHERE, 1995, 30 (04) :789-800
[8]  
MILLER MJ, 1980, FED PROC, V39, P998
[9]  
MIMURA M, 1993, DRUG METAB DISPOS, V21, P1048
[10]  
NORBACK DH, 1981, RES COMMUN CHEM PATH, V32, P71
12