LIPASE-CATALYZED ENANTIOSYNTHESIS OF (R)- AND (S)-2-[BENZYL(PHENYL)AMINO]ETHYL 5-(5,5-DIMETHYL-2-OXO-1,3,2-DIOXAPHOSPHORINAN-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3-PYRIDINECARBOXYLATE (NZ 105)

被引：0

作者：

EBIIKE, H ^{[1
]}

YAMAZAKI, Y ^{[1
]}

ACHIWA, K ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, SHIZUOKA 422, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1995年 / 43卷 / 07期

关键词：

1,4-DIHYDROPYRIDINE; CALCIUM CHANNEL BLOCKER; NZ; 105; LIPASE-CATALYZED ENANTIOSELECTIVE SYNTHESIS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Homochiral 4-Aryl-1,4-dihydropyridine-5-phosphate (NZ 105) was synthesized from the racemic materials. The enantioselective hydrolysis by lipase catalyst was smoothly proceeded and optically active carboxylic acid was converted into optically active medicine.

引用

页码：1251 / 1253

页数：3

共 6 条

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[3] 1,4-DIHYDROPYRIDINES - EFFECTS OF CHIRALITY AND CONFORMATION ON THE CALCIUM-ANTAGONIST AND CALCIUM AGONIST ACTIVITIES [J].

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