RELATIONSHIP BETWEEN AGING AND SUSCEPTIBILITY TO PROTEIN OXIDATIVE DAMAGE

被引：47
作者：
AGARWAL, S [1 ]
SOHAL, RS [1 ]
机构：
[1] SO METHODIST UNIV,DEPT BIOL SCI,DALLAS,TX 75275
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 03期
关键词：
D O I：
10.1006/bbrc.1993.1950
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The objective of this study was to determine if the susceptibility of tissues to experimental oxidative damage is altered during the aging process. Adult houseflies were X-irradiated at different dosages, when they had reached 0.25 and 0.70 of their average life expectancy. Protein carbonyl content and activity of glucose-6-phosphate dehydrogenase were used as indices of oxidative damage. Fly homogenates as well as the live flies were more susceptible to oxidative damage at the older than at the younger age. © 1993 Academic Press, Inc.
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页码：1203 / 1206
页数：4
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