HUMAN SOMATIC MUTATION ASSAYS AS BIOMARKERS OF CARCINOGENESIS

被引：25

作者：

COMPTON, PJE ^{[1
]}

HOOPER, K ^{[1
]}

SMITH, MT ^{[1
]}

机构：

[1] CALIF DEPT HLTH SERV,CALIF OCCUPAT HLTH PROGRAM,DIV HLTH HAZARD ASSESSMENT,BERKELEY,CA 94704

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 1991年 / 94卷

关键词：

D O I：

10.2307/3431307

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay. Somatic gene mutation can be considered a biomarker of carcinogenesis, and assays for somatic mutation may assist epidemiologists in studies that attempt to identify factors associated with increased risks of cancer. Practical aspects of the use of these assays are discussed.

引用

页码：135 / 141

页数：7

共 65 条

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